International Review of Cytology (eBook)

Cover 1
Copyright Page 5
Contents 6
Contributors 10
Chapter 1. Cell and Molecular Biology of the Multifunctional Peptide, Adrenomedullin 12
I. Introduction 12
II. Gene Structure and Regulation of Gene Expression 13
III. Receptors for Adrenomedullin and Related Peptides 19
IV. Adrenomedullin Serum-Binding Protein 25
V. Distribution of AM and PAMP in Healthy Organs and Tissues 27
VI. Functions of Adrenomedullin 42
VII. Role of Adrenomedullin in Pathological States 54
VIII. Manipulation of Adrenomedullin Levels 64
IX. Conclusions, Open Questions, and Future Perspectives 66
References 67
Chapter 2. Molecular Mechanisms of Cerebral Ischemia-Induced Neuronal Death 104
I. Introduction 105
II. Neuronal Death 110
III. Catastrophe in the Endoplasmic Reticulum 115
IV. Mitochondrial Catastrophe 119
V. Oxidative Stress 122
VI. DNA Damage and Cerebral Ischemia 124
VII. Altered Gene Expression following Cerebral Ischemia 126
VIII. Neuroprotection in Cerebral Ischemia 135
IX. Conclusion 140
References 141
Chapter 3. Application of Comparative Genomics in Fish Endocrinology 160
I. Introduction 161
II. Comparative Genomics 166
III. Impact of Comparative Genomics on Fish Endocrinology 173
IV. Summary 193
References 194
Chapter 4. Protein Transport into Secondary Plastids and the Evolution of Primary and Secondary Plastids 202
I. Introduction 203
II. Evolution of Plastids by Endocytobiosis 205
III. Translocation Systems for Plastid Protein Targeting 217
IV. Evolutionary Considerations 245
V. Prospects 247
References 248
Chapter 5. Conserved Features of Endocytosis in Dictyostelium 268
I. Introduction 268
II. Endocytic Uptake at the Plasma Membrane 269
III. Progression through Endosomal Compartments 280
IV. Retrograde Membrane Flow 284
V. Exocytosis 285
VI. Osmoregulation 286
VII. Concluding Remarks 287
References 289
Index 300