Interaction Between Neurons and Glia in Aging and Disease (eBook)
IX, 521 Seiten
Springer US (Verlag)
978-0-387-70830-0 (ISBN)
A superb source of reference reviews as well as a concise overview of the functional cross-talk between neurons and glial cells, this book also focuses on microglia and inflammation in the aging brain and in neurological disorders. The scientific spectrum covered by this book is of key interest, and is recognized by the scientific community as a major competitive area with critical implications for human health.
Interactions Between Neurons and Glia in Aging and Disease is a source of "e;reference reviews"e; and "e;concise overviews"e; of the functional cross-talk between neurons and glial cells, with a focus on microglia and inflammation in the aging brain and in neurological disorders. The scientific area covered by this book may be considered of key interest, and it is recognized, by the scientific community, as a major competitive area with critical implications for human health.This book is organized in three main sections that are expected to guide the readers from the basic functional cross-talk between neuron and glia to brain pathology. The specific proposed sections are: 1) Neuroimmunity and Neuroinflammation; 2) Signalling and inflammation in aging; 3) Neurodegeneration and inflammation in age related diseases.
Contents 7
NEUROIMMUNITY AND NEUROINFLAMMATION 10
INFLAMMATION AND NEURONAL SUSCEPTIBILITY TO EXCITOTOXIC CELL DEATH 12
MICROGLIAL CELL POPULATION EXPANSION FOLLOWING ACUTE NEURAL INJURY 45
OPPOSITE MODULATION OF PERIPHERAL INFLAMMATION AND NEUROINFLAMMATION BY ADENOSINE A2A RECEPTORS 61
SUBVENTRICULAR ZONE CELLS AS A TOOL FOR BRAIN REPAIR 88
SIGNALING AND INFLAMMATION IN AGING 116
THE IMPACT OF AN IMBALANCE BETWEEN PROINFLAMMATORY AND ANTI- INFLAMMATORY INFLUENCES ON SYNAPTIC FUNCTION IN THE AGED BRAIN 128
NEUROTROPHIN SIGNALING AND CELL SURVIVAL 144
GDNF: A KEY PLAYER IN NEURON–GLIA CROSSTALK AND SURVIVAL OF NIGROSTRIATAL DOPAMINERGIC NEURONS 180
MOLECULAR PATHWAYS OF MITOCHONDRIAL DYSFUNCTION IN NEURODEGENERATION: THE PARADIGMS OF PARKINSON’S AND HUNTINGTON’S DISEASES 200
ZINC HOMEOSTASIS AND BRAIN INJURY 227
AGING AND COGNITIVE DECLINE: NEUROPROTECTIVE STRATEGIES 251
NEURODEGENERATION AND INFLAMMATION IN AGE RELATED DISEASES 275
INFLAMMATION AND APOPTOTIC PATHWAYS IN THE PERIPHERAL NERVOUS SYSTEM RELATED TO PROTEIN MISFOLDING 277
NEUROINFLAMMATION AND EXCITOTOXICITY IN NEUROBIOLOGY OF HIV- 1 INFECTION AND AIDS: TARGETS FOR NEUROPROTECTION 287
NEUROINFLAMMATION AND MITOCHONDRIAL DYSFUNCTION IN ALZHEIMER’S AND PRION’S DISEASES 315
METAL IONS AND ALZHEIMER’S DISEASE 338
EPILEPSY, BRAIN INJURY, AND CELL DEATH 367
GLIA AND HIPPOCAMPAL NEUROGENESIS IN THE NORMAL, AGED AND EPILEPTIC BRAIN 379
POLYGLUTAMINE EXPANSION DISEASES – THE CASE OF MACHADO- JOSEPH DISEASE 395
REMYELINATION OF THE CENTRAL NERVOUS SYSTEM 431
ADULT NEUROGENESIS IN NEURODEGENERATIVE DISEASES 448
ATP RECEPTORS IN THE PAIN SIGNALING: GLIAL CONTRIBUTION IN NEUROPATHIC PAIN 464
DIABETIC RETINOPATHY, INFLAMMATION, AND PROTEASOME 478
REJUVENATING NEURONS AND GLIA WITH MICROBIAL ENZYMES 506
Abbreviations 514
Index 516
| Erscheint lt. Verlag | 9.8.2007 |
|---|---|
| Mitarbeit |
Stellvertretende Herausgeber: Ana Cristina Rego, Rodrigo Cunha, Catarina Oliveira |
| Zusatzinfo | IX, 521 p. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Humanbiologie | |
| Naturwissenschaften ► Biologie ► Zoologie | |
| Schlagworte | adenosine • aging • Disease • Glia • nervous system • neurons • Parkinson |
| ISBN-10 | 0-387-70830-8 / 0387708308 |
| ISBN-13 | 978-0-387-70830-0 / 9780387708300 |
| Haben Sie eine Frage zum Produkt? |
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