Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy (eBook)

Contents 6
List of contributors 8
Acknowledgements 10
Foreword 11
Section A: Bipolar depression: Clinical phenotype and course of illness 13
The history of bipolar disorders 14
The clinical diagnosis of bipolar depression 28
Course and outcome of bipolar disorder – focusing on depressive aspects 40
Suicide and bipolar disorder 58
Section B: Bipolar depression: Neurobiology 68
The genetic basis of bipolar disorder 69
Understanding the neurobiology of bipolar depression 87
Non-pharmacological treatments and chronobiological aspects of bipolar disorder: implications for novel therapeutics 105
Neuroimaging studies of bipolar depression: therapeutic implications 127
Section C: Acute and long-term treatment of bipolar disorder 155
Pharmacological treatment of acute bipolar depression 156
Pharmacological treatment of the maintenance phase of bipolar depression: focus on relapse prevention studies and the impact of design on generalizability 168
Non-pharmacological somatic treatments for bipolar depression 188
Potential novel treatments for bipolar depression 200
Section D: Treatment of bipolar disorder in special populations 219
Late-onset bipolar disorder 220
Treatment of childhood-onset bipolar disorder 247
Treatment of bipolar disorder during and after pregnancy 259
Conclusion 276
Index 280
The MDT-Series Milestones in Drug Therapy 285