Ion Channels and Their Inhibitors

Satya Prakash Gupta (Herausgeber)

Buch | Hardcover
XIII, 348 Seiten
2011 | 2011
Springer Berlin (Verlag)
978-3-642-19921-9 (ISBN)
106,99 inkl. MwSt
Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with targets based on ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium Ion, potassium Ion, chloride Ion, calcium Ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, and neurobiology, and medicinal chemistry.

Structural and Functional Discrimination of Membrane.- Proteins.- Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.- Advanced Molecular Modeling Techniques Applied to Ion Channels Blockers.- Advances in Design and Development of Sodium Channel Blockers.- Potassium Channel Blockers as Anti-arrhythmic Agents.- hERG Potassium Channels in Drug Discovery and Development.- Prediction of hERG Channel Inhibition Using in silico Techniques.- Advances in Structure-Activity Relationship Studies on Potassium Channel Modulators.-

Calcium Ion Channels and Their Blockers.- Therapeutic Potential of N-type Voltage Gated Ca2+ Channel.- Chloride Ion Channels: Structure, Functions, and Blockers.

Erscheint lt. Verlag 23.6.2011
Zusatzinfo XIII, 348 p.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 690 g
Themenwelt Medizin / Pharmazie Pharmazie
Medizin / Pharmazie Studium
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Chemie Physikalische Chemie
Schlagworte Calcium Ion Channels • Chloride Ion Channel Inhibitors • HCN Channels • Ion Channel Blockers • ion channels • Ionen • Medizinische Chemie • Membrane Proteins • Potassium Ion Channel Inhibitors • QSAR • Sodium Ion Channel Inhibitors
ISBN-10 3-642-19921-6 / 3642199216
ISBN-13 978-3-642-19921-9 / 9783642199219
Zustand Neuware
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