Enzyme Catalysis in Organic Synthesis – A Comprehensive Handbook, Second Edition

Karlheiz Drauz is Vice President of International Scientific Relations of Evonik. He evaluates interesting topics in research and development and networks globally with academic and industrial institutions. He did his Ph.D. at the Technical University Stuttgart, Germany, and started his career at Degussa 1980 in various positions in research and development. His research interests include amino acids, peptides, biological active compounds, asymmetric synthesis, metal and biocatalysis as well as process chemistry. He holds about 160 patents, about 100 scientific publications. Since 1992 he is honorary professor for organic chemistry at the University Wurzburg, Germany. Herbert Waldmann obtained his PhD in organic chemistry from the University of Mainz, Germany, in 1985 working with Professor H. Kunz, after which he completed a postdoctoral appointment with Professor G. Whitesides at Harvard University - USA -. He was appointed as Professor of Organic Chemistry at the University of Bonn - 1991 -, full Professor of Organic Chemistry at the University of Karlsruhe - 1993 -, and Director at the Max-Planck-Institute of Molecular Physiology Dortmund and Professor of Organic Chemistry at the University of Dortmund, Germany, in 1999. He has received numerous awards, e.g. the Otto-Bayer-Award - 2001 -, the Max Bergmann Medal - 2003 -, and recently the Emil-Fischer-Prize - 2012 -. His research interests lie in bioactive compound development, target identification, and the chemical biology of Ras proteins.

Introduction Production and Isolation of Enzymes Rational Design of Functional Proteins Enzyme Engineering by Directed Evolution Enzyme Bioinformatics Immobilization of Enzymes Reaction Engineering for Enzyme-Catalyzed Biotransformations Enzymic Conversions in Organic and Other Low-Water-Media Enzymatic Kinetic Resolution Enzymes from Extreme Thermophilic and Hyperthermophilic Archaea and Bacteria Hydrolysis and Formation of C-O Bonds Hydrolysis and Formation of C-N Bonds Formation and Cleavage of P-O Bonds Formation of C-C Bonds Reduction Reactions Oxidation Reactions Isomerizations Introduction and Removal of Protecting Groups Replacing Chemical Steps by Biotransformations: Industrial Application and Processes Using Biocatalysis Tabular Survey of Commercially Available Enzymes