Asymmetric Synthesis with Chemical and Biological Methods

Dieter Enders completed his PhD at the Justus Liebig Universitat Giessen under the supervision of D. Seebach. After postdoctoral studies at Harvard University with E. J. Corey, he returned to Giessen and completed his habilitation. He became Associate Professor at the Universitat Bonn in 1980, and moved to his present position as Professor of Organic Chemistry at the RWTH Aachen in 1985. He has received many awards (Leibniz Prize of the DFG, Emil Fischer Medal of the GDCh, Yamada Prize, Japan) for his research, which focuses on the asymmetric synthesis of biologically active compounds and the development of new synthetic methods. Karl Erich Jaeger was born in Dortmund and studied biology and chemistry at the Ruhr University Bochum, where he received his PhD under the supervision of U. Winkler. After postdoctoral studies with Robert E.W. Hancock at the Department of Microbiology of the University of British Columbia in Vancouver, he received his habilitation in Bochum in 1995. Karl Erich Jaeger is currently Professor at the Heinrich Heine University of Dusseldorf and Director of the Institute of Molecular Enzyme Technology at the Research Centre Julich. His research interests include the expression, folding and secretion of bacterial enzymes, their optimization by directed evolution, and enantioselective biocatalysis.

STOICHIOMETRIC ASYMMETRIC SYNTHESIS Development of Novel Enantioselective Synthetic Methods Asymmetric Synthesis of Natural Products Employing the SAMP/RAMP-Hydrazone Methodology Asymmetric Synthesis Based on Sulfonimidoyl-Substituted Allyltitanium Complexes The "Daniphos" Ligands: Synthesis and Catalytic Applications New Chiral Ligands Based on Substituted Heterometallocenes CATALYTIC ASYMMETRIC SYNTHESIS WITH CHEMICAL METHODS Sulfoximines as Ligands in Asymmetric Metal Catalysis Catalyzed Asymmetric Aryl Transfer Reactions Substituted [2.2]-Paracyclophane Derivatives as Efficient Ligands for Asymmetric 1,2- and 1,4-Addition Reactions Palladium-Catalyzed Allylic Alkylation of Sulfur and Oxygen Nucleophiles - Asymmetric Synthesis, Kinetic Resolution and Dynamic Kinetic Resolution The QUINAPHOS Ligand Family and its Application in Asymmetric Synthesis Immobilization of Transition Metal Complexes and their Application to Enantioselective Catalysis CATALYTIC ASYMMETRIC SYNTHESIS WITH BIOLOGICAL METHODS Directed Evolution to Increase the Substrate Range of Benzoylformate Decarboxylase from Pseudomonas Putida C-C Bonding Microbial Enzymes: Thiamine Diphosphate-Dependent Enzymes and Class I Aldolases Enzymes for Carboligation - 2-Ketoacid Decarboxylases and Hydroxynitrile Lyases Preparative Syntheses of Chiral Alcohols using (R)-specific Alcohol Dehydrogenases from Lactobacillus strains Biocatalytic C-C Bond Formation in Asymmetric Synthesis Exploring and Broadening the Biocatalytic Properties of Recombinant Sucrose Synthase 1 for the Synthesis of Sucrose Analogues Flexible Asymmetric Redox Reactions and C-C Bond Formation by Bioorganic Synthetic Strategies REACTION TECHNOLOGY IN ASYMMETRIC SYNTHESIS Reaction Engineering in Asymmetric Synthesis Biocatalyzed Asymmetric Syntheses Using Gel-Stabilized Aqueous-Organic Two-Phase Systems