Biophotonics – Visions for Better Health Care

Marion Strehle studied biology and chemistry at the university W?g where she finished her PhD thesis 2003. During her PostDoc time at the Friedrich Schiller University Jena her research interests were focused on the development of innovative bio-spectroscopical methods for a fast, robust and very sensitive quality control of natural products. In addition to her research activities she was responsible for the public relation of the 2002 founded research framework "Biophotonik", funded by the BMBF, and for the organization of the international Bunsen discussion meeting "Raman and IR spectroscopy in Biology and Medicine" (2004) and the biophotonic symposium "Struktur und Dynamik biologischer Zellen mit optischen Methoden auf der Spur" (2005). Jurgen Popp received his Ph.D. in chemistry from the University of Wurzburg in 1995 and joined the group of Prof. Dr. Dr. h.c. W. Kiefer, University of Wurzburg, where he finished his habilitation. He became full professor at the University of Jena and Director of the Institute of Physical Chemistry. Since 2002 he has been speaker of the research framework "Biophotonik" funded by the BMBF. In 2005, he became Head of the Microsystem Devision of the Institute of Physical High Technology. His work has been awarded the faculty prize of chemistry (1995), the Bayerischer Habilitationsforpreis (1997), the Forderpreis der Wuger Korporationen (2001), and the Kirchhoff-Bunsen award (2002).

List of Contributors.1 Introduction: Biophotonics - Visions for Better Health Care (S. Liedtke, M. Schmitt, M. Strehle, J. Popp).1.1 The Situation of Biophotonics in Germany and Other Countries.1.2 Interplay between light and matter.1.3 A Fascinating Tour Across Biophotonics.1.4 Links and Literature about Biophotonics.2 Online Monitoring of Airborne Allergenic Particles (OMNIBUSS) (S. Scharring, A. Brandenburg, G. Breitfuss, H. Burkhardt, W. Dunkhorst, M. v. Ehr, M. Fratz, D. Giel, U. Heimann, W. Koch, H. Lodding, W. Muller, O. Ronneberger, E. Schultz, G. Sulz, Q. Wang).2.1 Introduction.2.2 Monitoring Bioaerosols: State-of-the-Art.2.3 Online Monitoring of Airborne Allergenic Particles by Microscopic Techniques.2.4 Summary / Outlook.Glossary.Key References.References.3 Online Monitoring and Identification of Bioaerosol (OMIB) (P. Rosch, M. Harz, M. Krause, R. Petry, K.-D. Peschke, H. Burkhardt, O. Ronneberger, A. Schule, G. Schmauz, R. Riesenberg, A. Wuttig, M. Lankers, S. Hofer, H. Thiele, H.-W. Motzkus, J. Popp).3.1 Bioaerosol and the Relevance of Microorganisms.3.2 Diagnosis of Microorganisms: State-of-the-Art.3.3 Innovative Optical Technologies to Identify Bioaerosol.3.4 Instrumentation of a Fully Automated Microorganism Fingerprint Sensor.3.5 Outlook.Glossary.Key References.References.4 Novel Singly Labelled Probes for Life Science Applications (SMART PROBES) (O. Nolte, M. Muller, B. Hafner, J. P. Knemeyer, K. Stohr, J. Wolfrum, R. Hakenbeck, D. Denapaite, J. Schwarz-Finsterle, S. Stein, E. Schmitt, C. Cremer, D. P. Herten, M. Hausmann, M. Sauer).4.1 Introduction: The Requirement for Novel Probes.4.2 The Principle of SMART PROBES.4.3 Instrumentation.4.4 Applications.4.5 Summary / Outlook.Glossary.Key References.References.5 Early Diagnosis of Cancer (PLOMS) (J. Helfmann, U. Bindig, B. Meckelein, K. Wehry, N. Rockendorf, D. Schadel, M. A. Schmidt,M. Burger, A. Frey).5.1 Cancer: Epidemiological, Medical and Biological Background.5.2 Diagnosing Cancer: State-of-the-Art.5.3 Emerging Optical Techniques in Cancer Diagnosis.5.4 The Future of Fluorescence Techniques in Cancer Diagnosis.5.5 Summary.Glossary.Key References.References.6 New Methods for Marker-free Live Cell and Tumor Analysis (MIKROSO) (G. v. Bally, B. Kemper, D. Carl, S. Knoche, M. Kempe, C. Dietrich, M. Stutz, R. Wolleschensky, K. Schutze, M. Stich, A. Buchstaller, K. Irion, J. Beuthan, I. Gersonde, J. Schnekenburger).6.1 Introduction.6.2 Cellular Analysis by Interference-basedMicroscopy.6.3 Minimally Invasive Holographic Endoscopy.6.4 Ultrasensitive Interference Spectroscopy for Marker-free Biosensor Technology.6.5 Outlook.Glossary.Key References.References.7 Regenerative Surgery (MeMo) (V. Andresen, H. Spiecker, J. Martini, K. Tonsing, D. Anselmetti, R. Schade, S. Grohmann, G. Hildebrand, K. Liefeith).7.1 Regenerative Surgery and Tissue Engineering: Medical and Biological Background.7.2 State-of-the-art and Markets.7.3 Cell and Tissue Culture Technologies.7.4 Controlled Tissue Cultivation Through Laser Optical Online Monitoring.7.5 Characterization and Evaluation of Tissues by Innovative Biophotonic Technologies.7.6 Results and Application.7.7 Summary and Outlook.Glossary.Key References.References.8 Microarray Biochips - Thousands of Reactions on a Small Chip (MOBA) (W. Monch, J. Donauer, B. M. Fischer, R. Frank, G. Gauglitz, C. Glasenapp, H. Helm, P. Hing, M. Hoffmann, P. Uhd Jepsen, T. Kleine-Ostmann, M. Koch, H. Krause, N. Leopold, T. Mutschler, F. Rutz, T. Sparna, H. Zappe).8.1 Introduction.8.2 Microarrays: Biological Background.8.3 Fluorescence Techniques.8.4 Optical Systems for Fluorescence Analysis.8.5 Label-free Techniques.8.6 Terahertz Spectroscopy.8.7 Outlook.Glossary.Key References.References.9 Hybrid Optodes (HYBOP) (D. Gansert, M. Arnold, S. Borisov, C. Krause, A. Muller, A. Stangelmayer, O. Wolfbeis).9.1 Introduction.9.2 Optical Sensors - State-of-the-Art.9.3 Planar and Fibrous Optodes - New Optical Tools for Non- and Minimally Invasive Analysis.9.4 Fluorescence Optical Hybrid Optodes - the Technology of Tomorrow.9.5 Hybrid Optodes: Applications and Perspectives in Biotechnology.9.6 Outlook.Glossary.Key References.References.10 Digital Microscopy (ODMS) (A. Nolte, C. Dietrich, L. Horing, N. Salmon, E.H.K. Stelzer, A. Riedinger, J. Colombelli, P. Denner, G. Langer, K. Parczyk, C.-D. Voigt, S. Prechtl, U. Lohrs, J. Diebold, V. Mordstein).10.1 Introduction.10.2 State-of-the-Art: Digital Microscopy.10.3 Life Science Applications of the ODMS.10.4 Summary and Future Trends.Glossary.Key References.References.11 Outlook: Further Perspectives of Biophotonics (S. Liedtke, M. Schmitt, M. Strehle, J. Popp).11.1 Future Research Topics.11.2 Promising Innovative Microscopy Techniques.References.Index.