Peptides – Chemistry and Biology

Norbert Sewald and Hans-Dieter Jakubke are the authors of Peptides: Chemistry and Biology, published by Wiley.

INTRODUCTION AND BACKGROUND FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES Definitions and main conformational features of the peptide bond Building blocks, classification and nomenclature Analysis of the covalent structure of peptides and proteins Three dimensional structure Methods of structural analysis BIOLOGICALLY ACTIVE PEPTIDES Occurrence and biological roles Biosynthesis Selected bioactive peptide families PEPTIDE SYNTHESIS Principles and objectives Protection of functional groups Peptide bond formation Racemization during synthesis Solid phase peptide synthesis (SPPS) Biochemical synthesis SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS Strategy and tactics Synthesis in solution Optimized strategies on polymeric support Ligation of unprotected peptide segments SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES Cyclopeptides Cystine peptides Glycopeptides Phosphopeptides Lipopeptides Sulfated peptides PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS Peptide design Modified peptides Peptidomimetics Pseudobiopolymers Macropeptides and de novo design of peptides and proteins COMBINATORIAL SYNTHESIS Parallel synthesis Synthesis of mixtures APPLICATION OF PEPTIDES AND PROTEINS Protein pharmaceuticals Large scale peptide synthesis Peptide pharmaceuticals Peptide drugs and new drug assays