Protein–Lipid Interactions – From Membrane Domains to Cellular Networks

Lukas Tamm studied Molecular Biology and Biophysics at the University of Basel (Switzerland) and at Cornell University. After obtaining his PhD in Biophysics from the University of Basel in 1982, he moved to Stanford University for postdoctoral work with H. M. McConnell. Returning to Basel, he was appointed as a junior faculty member before joining thefaculty of the University of Virgina in 1990. He currently holds a chair in Molecular Physiology and Biological Physics and served as director of heinterdisciplinary program in biophysics at the University of Virginia from 1999-2003.

Preface. List of Contributors. PART I: HOW LIPIDS SHAPE PROTEINS. 1. Lipid Bilayers, Translocons, and the Shaping of Polypeptide Structure (S. White, et al.). 2. Folding and Stability of Monomeric beta--Barrel Membrane Proteins (J. Kleinschmidt). 3. A Paradigm of Membrane Protein Folding: Principles, Kinetics and Stability of Bacteriorhodopsin Folding (P. Booth). 4. Post--Integration Misassembly of Membrane Proteins and Disease (C. Sanders). PART II: HOW PROTEINS SHAPE LIPIDS. 5. A Census of Ordered Lipids and Detergents in X--ray Crystal Structures of Integral Membrane Proteins (M. Wiener). 6. Lipid and Detergent Interactions with Membrane Proteins Derived from Solution Nuclear Magnetic Resonance (A. Arora). PART III: MEMBRANE PENETRATION BY TOXINS. 7. Lipid Interactions of a--Helical Protein Toxins (G. Anderluh & J. Lakey). 8. Membrane Recognition and Pore Formation by Bacterial Pore--forming Toxins (A. Heuck & A. Johnson). 9. Mechanism of Membrane Permeation and Pore Formation by Antimicrobial Peptides (Y. Shai). PART IV: MECHANISMS OF MEMBRANE FUSION. 10. Cell Fusion in Development and Disease (B. Podbilewicz & L. Chermomodik). 11. Molecular Mechanisms of Intracellular Membrane Fusion (O. Vites & R. Jahn). 12. Interplay of Proteins and Lipids in Virus Entry by Membrane Fusion (A. Lai, et al.). PART V: CHOLESTEROL, LIPID RAFTS, AND PROTEIN SORTING. 13. Protein--Lipid Interactions in the Formation of Raft Microdomains in Biololgical Membranes (A. Kusumi, et al.). 14. Protein and Lipid Partitioning in Locally Heterogeneous Model Membranes (P. Schwille, et al.). PART VI: TARGETING OF EXTRINSIC MEMBRANE PROTEIN MODULES TO MEMBRANES AND SIGNAL TRANSDUCTION. 15. In vitro and Cellular Membrane--binding Mechanisms of Membrane--targeting Domains (W. Cho & R. Stahelin). 16. Structure and Interactions of C2 Domains at Membrane Surfaces (D. Cafiso). 17. Structural Mechanisms of Allosteric Regulation by Membrane--binding Domains (B. Canagarajah, et al.). Subject Index.