DNA and RNA Binders – From Small Molecules to Drugs

Introduction Natural products Pyrrolobenzodiazepines Aptamer DNA-RNA recognition, polyamines Hairpin polyamides, mismatch recognition Platinum compounds Porphyrines, phenanthroline, clip-phen Peptide-DNA interactions CC-1065-type compounds Calicheamicins Acridine-4-carboxamide, minimal intercalator concept Topoisomerase inhibitors Bis and ter-benzimidazole topoI inhibitors Triple helix-specific ligands Metal complexes, ruthenium and rhodium compounds Ecteinascidins Use of library for G4 recognition Computer model, rational design of G4 compounds (anthr) Diamidine minor groove binding agents Cationic fullerenes, naphthalediimide Bleomycin, CC1065 hybrid molecules Ni-Co salen complexes RNA ligands Abasic sites recognition Rebeccamycin Derivatives