Animal Models of Dementia

General Introduction to Animal Models of Human Conditions.- Animal Models of Dementia: Ethical Considerations.- The Role of Rodent Models in the Drug Discovery Pipeline for Dementia.- Species, Strain, and Gender Issues in the Development and Validation of Animal Models of Dementia.- Transgenic and Gene Targeted Models of Dementia.- Transgenic Animals and Intellectual Property Concerns.- Pathological Validation of Animal Models of Dementia.- Behavioral Validation in Animal Models of Dementia.- Pharmacological Validation in Animal Models of Dementia.- Validation of Animal Models of Dementia: Neurochemical Aspects.- Validation of Dementia Models Employing Neuroimaging Techniques.- Drosophila melanogaster as a Model Organism for Dementia.- Caenorhabditis elegans as a Model Organism for Dementia.- Zebrafish (Danio rerio) as a Model Organism for Dementia.- Spontaneous Vertebrate Models of Alzheimer Dementia: Selectively Bred Strains (SAM Strains).- Lesion-Induced Vertebrate Models of Alzheimer Dementia.- Aβ Infusion and Related Models of Alzheimer Dementia.- APP-Based Transgenic Models: The PDAPP Model.- APP-Based Transgenic Models: The Tg2576 Model.- APP-Based Transgenic Models: The APP23 Model.- Presenilin-Based Transgenic Models of Alzheimer’s Dementia.- APOE-Based Models of “Pre-Dementia”.- TAU Models.- The 3xTg-AD Mouse Model: Reproducing and Modulating Plaque and Tangle Pathology.- Cognitive Dysfunction in Genetic Mouse Models of Parkinsonism.- Mouse Models of Metachromatic Leukodystrophy and Adrenoleukodystrophy.- Animal Models of Amyotrophic Lateral Sclerosis.- Animal Models of Frontotemporal Dementia.- CADASIL: Molecular Mechanisms and Animal Models.- Spontaneously Hypertensive Rat (SHR): An Animal Model of Vascular Brain Disorder.- Animals Models of Normal Pressure Hydrocephalus.- Animal Models of Traumatically-Induced Dementia.- Animal Models of Alcohol-Induced Dementia.- Animal Models of Metallic Dementia.