The Hepatobiliary System

by the Director The Hepatobiliary System: Retrospect and Prospect A Personal View.- Session 1 Membranes and Transport Mechanisms.- Membrane Structure.- Transport Through Biological Membranes.- Mechanism of Transport of Inorganic Ions into Bile.- Biochemical Studies on Bile Secretion.- On the Structure and Function of Ligandin and Z Protein.- Excretion of Xenobiotic Compounds in Bile.- Session 2 Structure and Function in the Hepatobiliary System.- The Fine Structure of Liver Cells.- Ultrastructural Changes Induced by Drugs.- Liver Damage and Regeneration after Poisoning.- Toxic Effects of Lithocholate on the Liver and Biliary Tree.- Fine Structure of the Biliary Tree.- Bile Duct Function in Biliary Secretion.- Kinetics of Hepatic Uptake and Excretion of Organic Anions.- Session 3 Bilirubin Conjugates.- Bilirubin Conjugates in Bile.- Comparative Studies on the Structures of Conjugated Bilirubin-IX? and Changes in Cholestasis.- Session 4A Bile Acids and Lipids I.- Some New Aspects of the Regulation of Cholesterol Biosynthesis and Metabolism of Mevalonate.- Bile Acid Metabolism and its Control.- Diurnal Variation in Bile Acid Biosynthesis.- Hepatic Transport of Bile Acids.- Formation, Metabolism and Excretion of Bile Salt Sulfates in Man.- The Alio Bile Acids.- Dissolution of Gallstones by Chenodeoxycholic Acid.- Session 4B Bile Acids and Lipids II.- The Enterohepatic Circulation of Bile Acids in Man.- Bile Phospholipids: Origin and Function.- Biliary Lipids in Pregnancy.- Session 5 Cholestasis.- Intrahepatic Cholestasis.- Molecular Pathology of Cholestasis.- List of Participants.- Appendix I. Recommendations on Bile Salt Nomenclature.- Index of Speakers and Participants in Discussions.