Cardiac Drug Therapy

CONTENTS 1 Beta-Blockers: The Cornerstone of Cardiac Drug Therapy NEW CONCEPTS BETA-RECEPTORS MECHANISM OF ACTION DOSAGE CONSIDERATIONS PHARMACOLOGIC PROPERTIES AND CLINICAL IMPLICATIONS SALUTARY EFFECTS OF BETA-ADRENERGIC BLOCKADE BETA BLOCKERS VS CALCIUM ANTAGONISTS /NITRATES INDICATIONS FOR BETA-BLOCKERS ADVICE AND ADVERSE EFFECTS INDIVIDUAL BETA BLOCKERS WHICH BETA-BLOCKER TO CHOOSE Please LIST HEADINGS for all chapters 2. Beta blocker Controversies 1 3 Angiotensin-converting Enzyme Inhibitors and Angiotensin II Receptor Blockers 53 Mechanism of Action, 55 ACE Inhibitors Versus Other Vasodilators, 57 Clinical Indications, 59 Contraindications, 64 Advice, Adverse Effects, Interactions, 65 Individual ACE Inhibitors, 67 Angiotensin II Receptor Blockers, 75 4. ACE Inhibitors Controversies 5 Calcium Antagonists (Calcium Channel Blockers) 81 Mechanism of Action, 81 Major Calcium Antagonists, 83 When to Choose a Calcium Antagonist, 93 Indications for Calcium Antagonists in the New Millennium, 94 Which Calcium Antagonist to Choose, 96 Combination of Calcium Antagonists with Beta-Blockers, Nitrates, or Digoxin, 98 6. Calcium Antagonists Controversies 7 Diuretics 103 Indications, 105 Thiazides, 106 Loop Diuretics, 106 Potassium-Sparing Diuretics, 112 Other Diuretics, 117 Potassium Chloride Supplements, 118 Important New Information from Clinical Trials, 123 8 Hypertension new headings to be up dated 127 Relevant Key Issues, 127 Definitions, 130 Nondrug Therapy, 133 Laboratory Work-Up, 134 Which Drugs to Choose, 134 Beta-Blockers, 148 Diuretics, 150 ACE Inhibitors and Angiotensin II Receptor Blockers, 155 Calcium Antagonists (Extended Release), 160 Centrally Acting Drugs, 163 Alpha1-Blockers, 164 Hypertensive Crisis, 166 9 . Hypertension Controversies 10 Management of Angina 179 Salient Clinical Features, 179 Treatment of Stable Angina, 180 Management of Unstable Angina, 194 Variant Angina (Prinzmetal's), 201 Recommendations, 203 11 Management of Acute Myocardial Infarction 209 New Terminology, 209 Therapeutic Implications, 209 Coronary Care Therapeutics, 216 Limitation of Infarct Size and Increased Survival, 221 Thrombolytic Therapy, 222 Beta-Blockers, 233 Nitrates, 235 Ace Inhibitors, 236 Statins, 237 Magnesium, 237 Management of Complications of Infarction, 238 Management of Non-ST-Elevation Myocardial Infarction, 248 12 Management of Heart Failure new headings to add 255 The Size of the Problem, 255 Diagnosis, 258 Basic Cause, 261 Factors Precipitating Heart Failure, 262 Pathophysiology, 263 Vasodilators, 265 Diuretics, 270 Beta-Blockers, 272 Inotropic Agents, 275 Drug Treatment of Systolic Heart Failure, 287 Management of Diastolic Heart Failure, 293 Management of Pulmonary Edema, 294 13. Heart Failure Controversies 14 Management of Cardiac Arrhythmias delete page numbers 301 Classification, 302 Diagnosis of Arrhythmias, 306 Management of Supraventricular Arrhythmias, 309 Ventricular Arrhythmias, 322 Ventricular Tachycardia, 324 Antiarrhythmic Agents, 328 Class IA, 328 Class IB, 333 Class IC, 337 Class II, 340 Class III, 342 15 Cardiac Arrest new headings 353 16 Management of Infective Endocarditis 375