The Vulnerable Atherosclerotic Plaque

Renu Virmani MD Medical Director, CVPath, International Registry of Pathology, Gaithersburg MD, USA Jagat Narula MD, PhD Professor of Medicine, Chief, Division of Cardiology, Associate Dean, University of California, Irvine, School of Medicine, Irvine, CA, USA Martin B. Leon MD Professor of Medicine, Center for Interventional Vascular Therapy, Columbia University Medical Center, New York NY, USA James T. Willerson MD President, The University of Texas Health Science Center at Houston, President-Elect and Medical Director, Texas Heart Institute, Houston TX, USA

PART 1 Introduction. 1 History of atherosclerosis and vulnerable plaque research. Mohammad Madjid, Ibrahim Aboshady, Samuel Ward Casscells, Renu Virmani &. James T Willerson. . PART 2 Pathology. 2 The pathology of vulnerable plaque. Renu Virmani, Allen P Burke, James T Willerson, Andrew Farb, Jagat Narula & Frank D Kolodgie. 3 Plaque rupture. Renu Virmani, Allen P Burke, Andrew Farb, Herman K Gold, Aloke V Finn & Frank D Kolodgie. 4 Plaque erosion. Frank D Kolodgie, Allen P Burke, Andrew Farb, David R Fowler, Robert Kutys, Thomas N Wight & Renu Virmani. 5 Pathogenesis and significance of calcification in coronary atherosclerosis. Allen P Burke, Frank D Kolodgie, Andrew Farb & Renu Virmani. 6 Adventitial and periadventitial fat inflammation and plaque vulnerability. Silvio Litovsky, Deborah Vela, Mohammad Madjid, Samuel Ward Casscells & James T Willerson. 7 Murine models of advanced atherosclerosis. Michael E Rosenfeld & Stephen M Schwartz. PART 3 Triggers for plaque rupture. 8 Physical and mechanical stress. Luis E Rohde & Richard T Lee. 9 Inflammation and matrix metalloproteinases. Zorina S Galis & Susan M Lessner. 10 Apoptosis in atherosclerosis. Mark M Kockx, Wim Martinet & Michiel Knaapen. PART 4 Diagnosis. 11 Emerging biomarkers of instability. Sotirios Tsimikas. 12 Ultrasonic detection of coronary disease. Mani A Vannan, Chowdhury Ahsan, Johan Verjans, Artiom Petrov & Jagat Narula. 13 Intravascular ultrasound for plaque characterization. D Geoffrey Vince & Anuja Nair. 14 Magnetic resonance imaging and intravascular magnetic resonance imaging. Hee Kwon Song, Ronald L Wolf, Jacob Schneiderman & Robert L Wilensky. 15 Radionuclide imaging. Johan Verjans & Jagat Narula. 16 Near-infrared spectroscopy. Pedro R Moreno, Barbara Marshik & James E Muller. 17 Intravascular thermography. Mohammad Madjid, Morteza Naghavi, Silvio Litovsky, Samuel Ward Casscells & James T Willerson. 18 Optical coherence tomography. Paul Magnin & Evelyn Regar. 19 Intravascular palpography. Johannes A Schaar, Chris L de Korte, Frits Mastik, Pim de Feyter, Cornelis J Slager, Anton FW van der Steen & Patrick W Serruys. 20 Coronary computed tomography for the detection of atherosclerotic plaque. burden. Allen J Taylor & Irwin M Feuerstein. PART 5 Management. 21 New developments in treatment of vulnerable plaques. Mohammad Madjid, Silvio Litovsky, James T Willerson& Samuel Ward Casscells. 22 Photodynamic therapy. Ron Waksman & Pauline E McEwan. 23 Thermal stabilization of vulnerable plaques. Samuel Ward Casscells, Birendra N Lal, Mohammad Madjid, Tarun Tewatia, Ibrahim Aboshady, Yong-Jian Geng & James T Willerson. 24 An interventionalist's perspective. Aloke V Finn, Ronald Waksman & Herman Gold. 25 Genetic modulation of vulnerable plaques. Chunming Dong & Pascal J Goldschmidt-Clermont. Index