Toxicology of the Kidney

Part 1 Basic principles: anatomy and physiology of the kidney - a brief review; functional assessment of the kidney. Part 2 General features and mechanisms of nephrotoxicity: overview of clinical nephrotoxicity; morphological features of acute renal failure; pathophysiology of acute renal failure, mechanisms of glomerular injury; biochemical heterogeneity and site-specific tubular injury. Part 3 Specific nephrotoxicants - therapeutics: nephrotoxicity of protein overloading; the nephrotoxicity Of Beta-Lactam Antibiotics; The Nephrotoxicity Of Antineoplastic Drugs; analgesic nephrotoxicity; nephrotoxicity of cyclosporine and other immunosuppressive and immunotherapeutic agents; pathogenesis and therapeutic aspects of radiocontrast-induced renal dysfunction. Part 4 Specific nephrotoxicants - environmental chemicals: aliphatic halogenated hydrocarbons; nephrotoxicity of bromobenzene - the role of quinone- thioethers; mechanisms of metal-induced nephrotoxicity; the effects of selected fungal toxins on renal function; male rat-specific light hydrocarbon nephropathy; renal carcinogenesis.