Familial Cardiomyopathies

Echocardiography to Assess Cardiac Structure and Function in Genetic Cardiomyopathies.- MRI Quantification of Cardiac Structure and Function in Cardiomyopathy Patients.- Atomistic Simulations of Sarcomere Proteins.- Design Principles and Benefits of Spatially Explicit Models of Myofilament Function.- Computational Modeling of Cardiac Electrophysiology.- Computational Modeling and Simulation of the Fibrotic Human Atria.- A Semi-Automatic Pipeline for Generation of Large Cohorts of Four-Chamber Heart Meshes.- Genomic Engineering of Induced Pluripotent Stem Cell-Derived Cardiomyocytes.- The GENTIL Method for Isolation of Human Adult Cardiomyocytes from Cryopreserved Tissue for Proteomic Analyses.- Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin Filaments.- Protocols for Myosin and Actin-Myosin Assays using Rapid, Stopped-Flow Kinetics.- Measuring the Contractile Kinetics of Isolated Myofibrils from Human-Induced Pluripotent Stem Cell Derived Cardiomyocyte (hiPSC-CM) Models of Cardiomyopathy.