Gender Affirming Hormone Therapy in Humans

Jeffrey Zajac is Professor and Head of the University of Melbourne and Chair of Department of Medicine at Austin Health. He is a Clinical Endocrinologist and General Physician with research interests in molecular endocrinology. Professor Zajac trained in Medicine at the University of Melbourne and undertook a PhD. Following postdoctoral work in the Endocrine Genetics Unit at Massachusetts General Hospital, Boston, he returned to the University of Melbourne initially at Royal Melbourne Hospital and now Austin Health. His research group has embarked on a major research program investigating the effect of androgen deprivation therapy in patients with prostate cancer. These investigations include effects on bone, muscle, cardiovascular risk and metabolic state. He also heads a molecular endocrinology group investigating the androgen receptor using genetically modified mice. His clinical interests include general endocrinology, the use, misuse and abuse of testosterone, and transgender medicine.

1. Introduction to transgender animal models, advantages and disadvantages and relevance to humans
2. Male to Female and Female to Male models, controls
3. Cross gender hormone effects on bone
4. Cross gender hormone effects on the CVS and blood pressure
5. Cross gender hormone effects on the immune system
6. Cross gender hormone effects on muscle
7. Cross gender hormone effects on body composition
8. Cross gender hormone effects the kidney
9. Cross gender hormone effects on wound healing
10. Cross gender hormone effects on the CNS
11. Conclusion