DNA-encoded Library Technology for Drug Discovery -

DNA-encoded Library Technology for Drug Discovery

Buch | Hardcover
189 Seiten
2025
Royal Society of Chemistry (Verlag)
978-1-78801-487-8 (ISBN)
185,80 inkl. MwSt
This book provides a comprehensive guide to to the implementation of DNA-encoded library technology (DELT) in drug discovery for screening and hit validation.
DNA-encoded libraries have numerous advantages over traditional screening methods, including easy identification of compounds and the large quantity of compounds that can be screened simultaneously.



This book provides a comprehensive guide to the implementation of DNA-encoded library technology (DELT) in drug discovery for screening and hit validation, illustrated with successful case studies.



A valuable resource for researchers in drug discovery, this book is complete with successful case studies to illustrate the best practice in implementation and operation of DELT.

Purdue University, USA

Overview of Affinity-based DEL Selections with Select Target Types and Achievements
Machine Learning with DEL Selection Data and for DEL design
One bead one compound (OBOC) DELs for Biochemical Screens
Live cell-based DEL Selections
On-DNA Medicinal Chemistry: Focused libraries, fragment expansion, and hit optimization
DELs with Covalent Warheads
Application of DELs for E3 Ligase Ligand and PROTAC development

Erscheint lt. Verlag 21.2.2025
Reihe/Serie Drug Discovery ; Volume 85
Verlagsort Cambridge
Sprache englisch
Maße 156 x 234 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Naturwissenschaften Chemie Organische Chemie
ISBN-10 1-78801-487-1 / 1788014871
ISBN-13 978-1-78801-487-8 / 9781788014878
Zustand Neuware
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