Handbook of Pharmacology and Physiology in Anesthetic Practice

SECTION I: PHARMACOLOGY 1 1. Pharmacokinetics and Pharmacodynamics of Injected and Inhaled Drugs 3 2. Inhaled Anesthetics 45 3. Opioid Agonists and Antagonists 81 4. Barbiturates 119 5. Benzodiazepines 133 6. Nonbarbiturate Intravenous Anesthetic Drugs 151 7. Local Anesthetics 179 8. Neuromuscular-Blocking Drugs 211 9. Anticholinesterase Drugs and Cholinergic Agonists 251 10. Anticholinergic Drugs 267 11. Cyclooxygenase-2 Inhibitors and Nonspecific Nonsteroidal Anti-inflammatory Drugs 277 12. Sympathomimetics 293 13. Digitalis and Related Drugs 313 14. The-and-Adrenergic Receptor Antagonists 325 15. Antihypertensive Drugs 345 16. Peripheral Vasodilators-Nitric Oxide and Nitrovasodilators 359 17. Cardiac Antidysrhythmic Drugs 375 18. Calcium Channel Blockers 395 19. Drugs Used for Psychopharmacologic Therapy 405 20. Prostaglandins 429 21. Histamine and Histamine Receptor Antagonists 441 22. Serotonin, Plasma Kinins, and Renin 457 23. Hormones as Drugs 469 24. Insulin and Oral Hypoglycemics 489 25. Diuretics 501 26. Antacids and Gastrointestinal Prokinetics 513 27. Anticoagulants 521 28. Antimicrobials 539 29. Chemotherapeutic Drugs 575 30. Antiepileptic Drugs 597 31. Drugs Used for Treatment of Parkinson's Disease 617 32. Drug Treatment of Lipid Disorders 623 33. Central Nervous System Stimulants and Muscle Relaxants 631 34. Vitamins, Dietary Supplements, and Herbal Remedies 641 35. Minerals and Electrolytes 661 36. Blood Components, Substitutes, and Hemostatic Drugs 681 37. Enteral and Parenteral Nutrition 697 38. Antiseptics and Disinfectants 707 SECTION II: PHYSIOLOGY 713 39. Cell Structure and Function 715 40. Body Fluids 733 41. Central Nervous System 741 42. Thermoregulation 777 43. Autonomic Nervous System 787 44. Pain 811 45. Systemic Circulation 829 46. Microcirculation and Lymphatics 849 47. Pulmonary Circulation 859 48. Heart 867 49. The Electrocardiogram and Analysis of Cardiac Dysrhythmias 883 50. The Lungs 897 51. Pulmonary Gas Exchange and Blood Transport of Gases 915 52. Acid-Base Balance 931 53. Endocrine System 943 54. Kidneys 961 55. Liver and Gastrointestinal Tract 983 56. Skeletal and Smooth Muscle 1001 57. Erythrocytes and Leukocytes 1009 58. Hemostasis and Blood Coagulation 1025 59. Metabolism of Nutrients 1033 60. Physiology of the Newborn and Elderly 1043 Drug Index 1059 Subject Index 1071