Practical Pharmaceutics

Paul Le Brun, PharmD, PhD, is hospital pharmacist and clinical pharmacologist of the Department of Clinical Pharmacy and Toxicology of Leiden University Medical Center, The Netherlands since 2017. He also teaches pharmacy students in quality, preparation and innovative medicines as associate professor at the university of Leiden.

Paul obtained his degree in pharmacy from the Groningen University in 1982. He started his career at the Dutch Laboratory of Pharmacists (LNA), department of the Royal Dutch Association of Pharmacists (KNMP). From 1985 until 1988 he was trained and worked as a hospital pharmacist in the Central Hospital Pharmacy of The Hague. He joined Merck Sharp&Dohme as production pharmacist from 1989 to 1992. From 1992 until 2017 he was director of production of the Central Hospital Pharmacy in The Hague combined with clinical tasks in Haga teaching hospital.

In 2001 he obtained his PhD: "Optimization of antibiotic inhalation therapy in Cystic Fibrosis.Studies on nebulized tobramycin. Development of a colistin dry powder inhaler system. The research was valued in 2000 with the KNMP Innovation Award. To date, his main research themes are Aseptic preparation and Medicinal product development.

Paul published numerous scientific papers and was author/editor of the first edition of Practical Pharmaceutics.Sylvie Crauste-Manciet obtained her degree in Pharmacy (PharmD) in 1993, her PhD in 1997 and accreditation to supervise research (HDR) in 2013 from the University of Paris Descartes, France. Until 1999, she combines hospital pharmacy and academic activities as specialist in pharmaceutical technologies for preparation of sterile and not sterile drugs for hospitalized patients e.g. cytotoxic drugs, parenteral nutrition, paediatric capsules in Paris, Bordeaux and she recently moved to Angers. As professor of pharmaceutical technologies, she developed specific research in nanosytems design and characterization firstly at UPCGI Laboratory, UMR 8151 CNRS- U1022 INSERM at Paris Descartes University then at ARNA, ChemBioPharm team, INSERM U1212 UMR 5320 CNRS at Bordeaux University and since September 2022 at MINT laboratory UMR INSERM 1066 /CNRS 6021 at Angers University. She created in 2016 a master's program dedicated for research on hospital pharmaceutical technology. Since 1998, she is the president of the European society of Hospital Pharmaceutical Technology (GERPAC) which is an association of European hospital pharmacists involved in the research and development of hospital preparations.

Sylvie Crauste-Manciet obtained her degree in Pharmacy (PharmD) in 1993, her PhD in 1997 and accreditation to supervise research (HDR) in 2013 from the University of Paris Descartes, France. Until 1999, she combines hospital pharmacy and academic activities as specialist in pharmaceutical technologies for preparation of sterile and not sterile drugs for hospitalized patients e.g. cytotoxic drugs, parenteral nutrition, paediatric capsules in Paris, Bordeaux and she recently moved to Angers. As professor of pharmaceutical technologies, she developed specific research in nanosytems design and characterization firstly at UPCGI Laboratory, UMR 8151 CNRS- U1022 INSERM at Paris Descartes University then at ARNA, ChemBioPharm team, INSERM U1212 UMR 5320 CNRS at Bordeaux University and since September 2022 at MINT laboratory UMR INSERM 1066 /CNRS 6021 at Angers University. She created in 2016 a master's program dedicated for research on hospital pharmaceutical technology. Since 1998, she is the president of the European society of Hospital Pharmaceutical Technology (GERPAC) which is an association of European hospital pharmacists involved in the research and development of hospital preparations.

Irene Krämer, PharmD, PhD, is Director of the Pharmacy Department of the University Medical Center at the Johannes Gutenberg-University Mainz (Germany) and Professor of Clinical Pharmacy at the faculty of pharmac

Chapter 1. Introduction (Paul Le Brun).- Chapter 2. Prescription Assessment (Andrew Loweya).- Chapter 3. Availability of medicines (Helena Jenzer).- Chapter 4. Product Design (Christien Oussoren).- Chapter 5. Biopharmaceutics (Henderik Frijlink).- Chapter 6.Physical Chemistry (Wouter Hinrichs).- Chapter 7. Raw Materials (Richard Lantink).- Chapter 8. Containers (Julian Smith).- Chapter 9. Microbiology (David Roesti).- Chapter 10. Impact on the environment (Bengt Mattson).- Chapter 11. Information Sources (Sin Ying Chuah).- Chapter 12. Oral solids (Boy van Basten).- Chapter 13. Oral Liquids (Antje  Lein).- Chapter 14. Pulmonary (A.H. de Boer).- Chapter 15. Oropharynx (Craig Russell).- Chapter 16. Nose (Anita Hafner).- Chapter 17. Ear (Monja Gantumur).- Chapter 18. Eye (Jens Boventer).- Chapter 19. Rectal and Vaginal (Herman Woerdenbag).- Chapter 20. Dermal (Antje  Lein).- Chapter 21. Parenterals (Marija Tubic-Grozdanis).- Chapter 22. Irrigations and Dialysis Solutions (Daan  Touw).- Chapter 23. Radiopharmaceuticals (Rogier Lange).- Chapter 24. Therapeutic Proteins and ATMPs (Michel Eppink).- Chapter 25. Human Resources (Elfriede Nusser-Rothermundt).- Chapter 26. Occupational safety (Johannes Gerding).- Chapter 27. Premises (Farshid Sadeghipour).- Chapter 28. Equipment (Derk Allersma).- Chapter 29. Basic Operations (Herman  Woerdenbag).- Chapter 30. Sterilisation Methods (Craig Russell).- Chapter 31. Aseptic Handling (Frits Boom).- Chapter 32. Production Quality Control and validation (Rogier Lange).- Chapter 33. Quality Requirements and Analysis (Mark Santillo).- Chapter 34. Stability (Daan Touw).- Chapter 35 Pharmaceutical Quality System (Reinout C.A. Schellekens).- Chapter 36. Risk management in pharmacy production (Elfriede Nusser Rothermundt).- Chapter 37. Documentation (Rik Wagenaar).-Chapter 38. Statistics (Pascal Odou).- Chapter 39. Logistics (Martin J. Hug).- Chapter 40. Product care and daily practice (Diana van Riet-Nales).