Bridging Laboratory and Field Research for Genetic Control of Disease Vectors

Lessons learnt and anticipated benefits.- Executive summary.- Report of the working-group meeting.- Review of previous applications of genetics to vector control.- Genomics and expected benefits for vector entomology.- Current state and future needs of laboratory and field science.- Genetic approaches for malaria control.- Current thoughts about the integration of field and laboratory sciences in genetic control of disease vectors.- Genetic approaches in Aedes aegypti for control of dengue: an overview.- Regional situation reports: malaria and dengue.- Malaria and dengue vector biology and control in West and Central Africa.- Malaria and dengue vector biology and control in Southern and Eastern Africa.- Malaria and dengue vector biology and control in Southeast Asia.- Malaria and dengue vector biology and control in Latin America.- Integration.- Transition from the laboratory to the field and effective interplay.- Evaluation of drive mechanisms (including transgenes and drivers) in different environmental conditions and genetic backgrounds.- Tools for monitoring the genetic structure and stability of mosquito populations.- What are relevant assays for refractoriness?.- Fitness studies: developing a consensus methodology.- Mosquito mating behaviour.- Pathogen evolution issues in genetically modified mosquito vector strategies.- Models to investigate some issues regarding the feasibility of driving refractoriness genes into mosquito vector populations.- Identification and characterization of field sites for genetic control of disease vectors.- Application of genetically modified mosquitoes in national vector control programmes: thoughts on integrated control.- Entomological correlates of epidemiological impacts: how do we know it is working?.- Ethical, legal and social issues in the use of genetically modified vectors for disease control.