Pharmacology in Drug Discovery and Development

Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

1. Pharmacology: The Chemical Control of Physiology
2. Drug Affinity and Efficacy
3. Predicting Agonist Effect
4. Drug Antagonism: Orthosteric Drug Effects
5. Allosteric Drug Effects
6. Enzymes as Drug Targets
7. Pharmacokinetics I: Permeation and Metabolism
8. Pharmacokinetics II: Distribution and Multiple Dosing
9. In Vivo Pharmacology
10. Safety Pharmacology
11. The science of Finding Drug Molecules I: Validating and Screening drug targets
12. The Science of Finding Drug Molecules II: Demonstrating Target Engagement and Therapeutic Value