Revising Oral Pharmacokinetics, Bioavailability and Bioequivalence Based on the Finite Absorption Time Concept

Panos Macheras is Professor emeritus in Biopharmaceutics Pharmacokinetics at the National and Kapodistrian University of Athens (NKUA) in Greece. He has received a BPharm from NKUA and a PhD (Pharmaceutical Chemistry) from NKUA and a PhD (Biopharmaceuitcs Pharmacokinetics) from Chelsea College (now King's College), University of London. His field of research covers Biopharmaceutics and Pharmacokinetics including classical modelling as well as fractal kinetics approaches. He has published over 180 research articles and 7 books, has supervised 15 PhD students, sits on the editorial board of several scientific journals and has received numerous awards for his scientific contributions. He has served as visiting associate professor at the University of Michigan, Ann Arbor, and is currently adjunct professor at the State University of New York, Buffalo. He also heads the PharmaInformatics Unit of the ATHENA Research Center in Athens, Greece.

Athanasios A. Tsekouras is associate professor in Physical Chemistry at the NKUA. He has received a BSc in Chemistry at NKUA and a PhD at Stanford University. He benefited from a four-year long postdoctoral research appointment at M.I.T. and a one-year appointment as an adjunct professor at the University of Washington, Pullman, working at Pacific Northwest National Laboratory, Richland, Wash. Since then, he has taught Thermodynamics and Spectroscopy at the Department of Chemistry in NKUA, while pursuing mostly research in Surface Science with vapor-deposited molecules that form electrically polarized films. Thus, he had the opportunity to introduce dozens of students in the tricks and pleasures of working with vacuum systems and doing original and unique research. All along, starting from his early undergraduate days, he has maintained a keen interest in model fitting in a variety of problems.

Part I: Oral Pharmacokinetics.- Chapter 1. From Bateman (1908) To Dost (1953).- Chapter 2. The Unphysical Hypothesis Of Infinite Absorption Time.- Chapter 3. The Finite Absorption Time (Fat) Concept.- Chapter 4. The Rise Of Physiologically Based Finite Time Pharmacokinetic (Pbftpk) Models.- Part II: Bioavailability-Bioequivalence.- Chapter 5. History Of The Bioavailability-Bioequivalence Concepts.- Chapter 6. Therapeutic Equivalence Based On Bioequivalence Studies.- Chapter 7. Bioavailability Under The Prism Of Finite Absorption Time.- Chapter 8. Bioequivalence Under The Prism Of Finite Absorption Time.