Potassium Channels And Their Modulators - John M Evans

Potassium Channels And Their Modulators

From Synthesis To Clinical Experience

(Autor)

Buch | Hardcover
424 Seiten
1996
Taylor & Francis Ltd (Verlag)
978-0-7484-0557-2 (ISBN)
429,95 inkl. MwSt
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An analysis of current potassium channel modulator research and development. The text covers the synthesis and structure-activity relationships of potassium channel modulators and their application to various target organs. An overview of clinical experience and future prospects is provided.
Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.

The synthesis and chemistry of benzopyran and related potassium channel activators, D.G. Smith; SAR of benzopyran potassium channel activators, J.M. Evans and G. Stemp; synthesis and SAR of pyridine-based potassium channel activators, M.N. Palfreyman; conformational studies of potassium channel activators, C. Edge; synthesis and SAR of potassium channel blockers, R. Crossley and A. Opalko; molecular biology of potassium channels, R. Latorre; electrophysiology of potassium channels, P.I. Aaronson and C.D. Benham; vascular effects of potassium channel activators - in vitro, U. Quast; vascular effects of potassium channel activators - in vivo, J.C. Clapham; cardiac potassium channel modulation - potential for antiarrhythmic therapy, M.C. Sanguinetti and J. Salata; cardiac effects of potassium channel modulators - anti-ischaemic, G. Gross; potassium channel activators - airway pharmacology and bronchial asthma, J.R.S. Arch; potassium channel modulators and the pancreas, J. Dunne; potassium channel activators and the genitourinary tract, A.F. Brading and W.H. Turner; potassium channel activators and the CNS, H. Herdon and N. Upton; potassium channel modulators - clinical experiences and future prospects, J. Colatsky and T.C. Hamilton.

Erscheint lt. Verlag 1.4.1996
Verlagsort London
Sprache englisch
Maße 178 x 254 mm
Gewicht 930 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
ISBN-10 0-7484-0557-7 / 0748405577
ISBN-13 978-0-7484-0557-2 / 9780748405572
Zustand Neuware
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