The Oxford Handbook of Opioids and Opioid Use Disorder

Kelly E. Dunn, PhD, MBA, is Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University. Dunn has been working in the field of opioid use disorder since 2005, motivated by witnessing her community be ravaged with nonmedical use of prescription opioids as a teenager. This led to a passion for understanding motivations for opioid use, identifying methods to prevent the onset of opioid use disorder, improving treatments for opioid use disorder, and exploring new methods for managing pain and reducing opioid reliance. She has built a robust portfolio of laboratory and clinical trial research investigating these questions and is an author of more than 100 peer-reviewed publications in the area of substance use and opioid use disorder.

Chapter 1: Historical Events that Shaped Contemporary Opioid Trends
Kelly E. Dunn

Chapter 2: Epidemiology of Opioid Use and Smoking, Alcohol, and Polysubstance Use Among Persons Using Opioids
Maria A. Parker and Whitney S. Cordoba-Grueso

Chapter 3 Opioid Use Disorder: Diagnostic History and Current Understanding
Orrin D. Ware and Kelly E. Dunn

Chapter 4: Access to Treatment for Opioid Use Disorder
Brendan Saloner and Jason Gibbons

Chapter 5: The Current Status of Medical Student Education on Opioids
Oluwole Jegede, Peter J. Na, Ismene Petrakis, and Srinivas B. Muvvala

Chapter 6: The Neurobiology of Opioid Use
Shailesh N. Khatri, Erin E. Maher, Emma O. Bondy, and Cassandra D. Gipson

Chapter 7: Genetic Influences in Opioid Use Disorder
Jill Rabinowitz and Brion Maher

Chapter 8: The Opioid Withdrawal Syndrome: Presentation, Measurement, and Management
Kelly E. Dunn, Cecilia Bergeria, Orrin D. Ware, Eric C. Strain

Chapter 9: Neonatal Abstinence Syndrome
Sarah H. Heil, Heidi S. Melbostad, and Leigh-Anne Cioffredi

Chapter 10: Opioid Craving: Understanding Its Measurement, Mechanisms, and Treatment
Cecilia Bergeria and Brandon Park

Chapter 11: Opioids and Cognition
Bethea A. Kleykamp, Shannon B. Clarke, and Shauna P. Acquavita

Chapter 12: Opioid Effects on Sleep: Review of the Literature and Consideration of the Hypothalamic-Pituitary-Adrenal Axis as a Relevant Mechanism
Jennifer D. Ellis, Chung Jung Mun, and Patrick H. Finan

Chapter 13: Fentanyl
Kelly E. Dunn, H. Elizabeth Bird, and Caitlyn J. Durgin

Chapter 14: Tramadol
Kelly E. Dunn, Judy Ashworth, and Eric C. Strain

Chapter 15: Kratom (Mitragyna speciosa): Pharmacology and Use of a Naturally Occurring Atypical Opioid
Kirsten E. Smith, Oliver Grundmann, Marc T. Swogger, and Albert Garcia-Romeu

Chapter 16: Ibogaine and Noribogaine
Deborah C. Mash and Michael Karukin

Chapter 17: Abuse Deterrent and Sustained Release Opioid Formulations
Rachel R. Luba, Sandra D. Comer, and Edward V. Nunes

Chapter 18: Methadone
Jonathan R. Buchholz, Molly Kalmoe, Justin Stamschror, and Andrew J. Saxon

Chapter 19: Buprenorphine
Eric C. Strain and Andrew Gaddis

Chapter 20: Naltrexone
Marina Tsoy-Podosenin and Evgeny Krupitsky

Chapter 21: Clonidine
Mark S. Gold and Kenneth Blum

Chapter 22: Lofexidine
Charles W. Gorodetzky, Kristen L. Gullo, and Marc Fishman

Chapter 23: Injectable Opioid Treatment
Eugenia Oviedo-Joekes

Chapter 24: Long-Term Treatment of Opioid Use Disorder With Medications
Aaron S. Wolfgang, Melissa B. Weimer, Peter J. Na, David A. Fiellin, and Srinivas B. Muvvala

Chapter 25: Supervised Withdrawal Opioid Use Disorder Treatments
Kelly E. Dunn and Andrew S. Huhn

Chapter 26: Psychosocial Treatment Methods
Jessica M. Peirce, Denis G. Antoine, Alexis S. Hammond, and Michael S. Kidorf

Chapter 27: Behavioral and Self-directed Treatments for Opioid Use Disorder
Wendy Insalaco and J. Gregory Hobelmann

Chapter 28: Contingency Management Treatment of Opioid Use Disorder
August F. Holtyn, Forrest Toegel, and Matthew D. Novak

Chapter 29: Treating Opioid Use During Pregnancy and Postpartum Life Phases
Hendrée E. Jones

Chapter 30: Pharmacy-Based Treatment Options for Opioid Use Disorder
Ali Cheetham and Suzanne Nielsen

Chapter 31: Opioid Overdose: Mechanisms and Naloxone
Jermaine D. Jones, Rachel R. Luba, Mudassir Mumtaz, and Felipe Castillo

Chapter 32: Opioid Overdose: Intervention Strategies
Laura Brandt

Chapter 33: Supervised Consumption Services
Jeanette Bowles, Meaghan Thumath, Gillian Kolla, Zoe Dodd, Jaime Arredondo Sanchez Lira, Frank Crichlow, and Leo Beletsky

Chapter 34: Psychiatric Comorbidities Among Persons Who Are Using Opioids
R. Kathryn McHugh

Chapter 35: Sex as a Biological Variable and Gender as a Social Construct in the Treatment of Opioid Use Disorder
Andrew S. Huhn

Chapter 36: Challenges of Opioid Use Disorder in Rural Settings
Stacey C. Sigmon and Jennifer R. Havens

Chapter 37: Differences Between Those Engaged in Heroin Use and Non-Prescribed Opioid Use
Ty S. Schepis, Bowie Duncan, and Katherine Vrotsos

Chapter 38: The Impact of Opioid Use Disorder on Families and Children
Erin L. Winstanley, Amanda Newhouse, and Kari-Beth Law