Adhesives in Biomedical Applications

Kashmiri Lal Mittal was employed by the IBM Corporation from 1972 through 1993. Currently, he is teaching and consulting worldwide in the broad areas of adhesion as well as surface cleaning. He has received numerous awards and honors including the title ofdoctor honoris causa from Maria Curie-Skłodowska University, Lublin, Poland. He is the editor of more than 150 books dealing with adhesion measurement, adhesion of polymeric coatings, polymer surfaces, adhesive joints, adhesion promoters, thin films, polyimides, surface modification surface cleaning, and surfactants. S. Neogi, PhD, is a full professor in the Department of Chemical Engineering, Indian Institute of Technology, Kharagpur, West Bengal, India. He gained his PhD from Ohio University and spent 10 years in industry in the U.S. He has about 70 research articles to his name as well as four patents granted.

Preface xiii

Part 1: General Topics 1

1 Historical Developments of Various Adhesives for Biomedical Applications 3
Nagavendra Kommineni, Raju Saka, Vaskuri G. S. Sainaga Jyothi, Arun Butreddy, Jyotsna G. Vitore and Wahid Khan

1.1 Origin of Adhesives 4

1.2 Prominence of Biomedical Adhesives in Wound Healing and Drug Delivery 5

1.3 Generations of Bioadhesives 8

1.4 Timeline of Developments and Advances 11

1.5 Current and Future Applications 12

1.6 Summary 16

2 Global Industry Development and Analysis of Adhesives for Biomedical Applications 25
Muhammed Yusuf Kandur, R. Hemamalini and Ebru Toksoy Öner

2.1 Introduction 25

2.2 Research Landscape of Bioadhesives 27

2.3 Sources of Bioadhesives for Biomedical Applications 29

2.4 Biomedical Applications of Bioadhesives 35

2.5 Latest Industrial Developments 38

2.6 Summary 42

3 Biomedical Adhesives 47
Jaehun Mun and Sungbaek Seo

3.1 Introduction 47

3.2 Types of Biomedical Adhesives and their Components 50

3.3 Advances in Adhesives Development for Biomedical Uses 64

3.4 Summary 66

3.5 Acknowledgements 66

4 Bioadhesion: Fundamentals and Mechanisms 71
Amit Porwal and Kamla Pathak

4.1 Introduction 71

4.2 Bioadhesion in Biological Systems 72

4.3 Bioadhesion/Mucoadhesion 73

4.4 The Mucosal Layer and Barriers to Drug Delivery 74

4.5 Barriers to Mucosal Drug Delivery 75

4.6 Factors Affecting Mucoadhesion 76

4.7 Mechanisms of Bioadhesion 79

4.8 Theories of Bioadhesion 81

4.9 Stages of Mucoadhesion 87

4.10 Modulation of Mucoadhesion 88

4.11 Molecular Biology in Bioadhesion 89

4.12 Administration of Bio- and Mucoadhesive Drug Delivery Systems 90

4.13 Prospects 93

4.14 Summary 93

Part 2: Specific Adhesives, Characteristics and Applications 99

5 Fibrin Glue: Sources, Characteristics and Applications 101
Anindya Karmaker and Shoeb Ahmed

5.1 Introduction 102

5.2 Evolution of Fibrin Glue 103

5.3 Types of Fibrin Adhesives and their Working Mechanisms 106

5.4 Production Methods of Commercial Fibrin Adhesives 109

5.5 Comparison of Some Commercial Fibrin Adhesives 111

5.6 Recent Developments and Future Trend of Fibrin Adhesives 114

5.7 Summary 115

6 Herbal Bioactives-Based Mucoadhesive Drug Delivery Systems 121
Shristhi Sohan Rawat, Arya Rai, Deepika Raina and Inderbir Singh

6.1 Introduction 121

6.2 Mucous Membrane 122

6.3 Theories of Adhesion 124

6.4 Mucoadhesive Polymers 128

6.5 Mucoadhesive-Based Drug Delivery Systems (DDS): Administration Routes 130

6.6 Clinical Studies 140

6.7 Patents on Herbal Bioactive--Based Mucoadhesive Drug Delivery Systems 141

6.8 Summary 143

7 Adhesive Hydrogels 151
Proma Bhattacharya and Sudarsan Neogi

7.1 Introduction 151

7.2 Mechanisms of Adhesion 156

7.3 Design Principles for Adhesive Hydrogels 160

7.4 Commonly Used Adhesive Hydrogels 161

7.5 Prospective Applications of Adhesive Hydrogels 166

7.6 Summary 167

8 Adhesives in Dermal Patches 177
Niharika Lal, Praveen Kumar Gaur and Navneet Verma

8.1 Introduction 178

8.2 Types of Dermal Patches 180

8.3 Evolution of Adhesives in Medical Applications 182

8.4 Types of Adhesives Used in Dermal Patches 184

8.5 Testing Physical Properties of PSAs 192

8.6 Prediction of Patch In Vivo Adhesive Performances 202

8.7 Adhesive Properties and Formulation Studies 203

8.8 Summary 204

9 Medical Adhesives from Extracted Mussel Adhesive Proteins 213
Yuvaraj Dinakarkumar, Annushrie Arravind and Niranjana Murali Mohan

9.1 Introduction 213

9.2 The Mussel Byssus 215

9.3 Mussel-Inspired Adhesion 219

9.4 Mussel-Inspired Tissue Adhesives 228

9.5 Summary 239

10 Dental Adhesives: State-of-the-Art, Current Perspectives, and Promising Applications 253
Lamia Sami Mokeem, Isadora Martini Garcia, Abdulrahman A. Balhaddad, Kevin Cline, Gabriel Rakovsky, Fabricio Mezzomo Collares and Mary Anne S. Melo

10.1 Introduction 254

10.2 Brief History of Dental Adhesive Systems 256

10.3 Classification and Composition of Adhesive Systems 258

10.4 Understanding the Challenges of Dental Adhesives Inside the Mouth 265

10.5 New Approaches Targeting Longevity of Adhesive-Dentin Interfaces 267

10.6 Dental Adhesives Endowed With Antibacterial Properties 268

10.7 Summary 270

10.8 Acknowledgments 270

11 Role of Adhesive-Based Systems for Diagnostic Imaging and Theranostic Applications 279
Aishee Dey and Sudarsan Neogi

11.1 Introduction 279

11.2 Role of Adhesives in Diagnostic Imaging 280

11.3 Theranostics 290

11.4 Summary 302

References 303

Index 313