Dementia with Lewy Bodies

John O'Brien is Professor of Old Age Psychiatry, Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle, UK Ian McKeith, MD, FRCPsych, FMedSci is Professor of Old Age Psychiatry at the Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK David Ames, BA, MD, FRCPsych, FRANZCP, is Professor of Psychiatry of Old Age, University of Melbourne and Director Aged Psychiatry Services, St George's Health Service, Melbourne, Victoria, Australia. Edmond Chiu, AM, MBBS, DPM, FRANZCP, is University of Melbourne Professorial Fellow in Psychiatry of Old Age and Psychiatrist, Aged Psychiatry Service, Melbourne, Victoria, Australia.

Introduction. Historical Background. The Clinical Spectrum of Lewy Body Disease. Classification and Diagnostic Criteria for DLB. Epidemiology. Neuropsychological Features. Neuropsychiatric Features. The Neurology of DLB. Auronomic Dysfunction. Neuroimaging. Longitudinal Course and Mortality. Pathology and Pathogenesis. Neurochemical Pathology. Molecular Biology and Genetics. Pharmacological Treatment. Non-pharmacological Management. The Caregivers Perspective. Dementia in Parkinson's Disease. Less Common Lewy Body Disorders and Atypical Parkinson Syndromes. Future Directions in Understanding and Treatment of Lewy Body Disease.