Biomedical Engineering Technologies

Development of a Multi-Target Protein Biomarker Assay for Circulating Tumor Cells.- Method to Isolate Dormant Cancer Cells from Heterogeneous Populations.- Label-Free Morphological Phenotyping of in vitro 3D Micro Tumors.- High-throughput microenvironment microarray (MEMA) (file #high-resolution imaging.- Real-Time Analysis of AKT Signaling Activities at Single-Cell Resolution Using Cyclic Peptide-Based Probes.- Microfluidic device technologies for digestion, disaggregation, and filtration of tissue samples for single cell applications.- Microdissection methods utilizing single cell subtype analysis and the impact on precision medicine.- Functionalized lineage tracing for the study and manipulation of heterogeneous cell populations.- Fluorescence lifetime imaging probes for cell-based measurements of enzyme activity.- Assessment of intracellular GTP levels using genetically encoded fluorescent sensors.- Node-Pore Sensing for characterizing cells and extracellular vesicles.- Affinity-Based Enrichment of Extracellular Vesicles with Lipid Nanoprobes.- Droplet magnetofluidic assay platform for quantitative methylation-specific PCR.- Droplette: A Platform Technology to Directly Deliver Nucleic Acid Therapeutics and Other Molecules into Cells and Deep into Tissue Without Transfection Reagents.- Molecular imaging of HER2 in patient tissues with touch prep-quantitative single molecule localization microscopy.- Microchip free-flow electrophoresis for bioanalysis, sensing and purification.- Green Chemistry Preservation and Extraction of Biospecimens for Multi-omic Analyses.- TdT-UTP DSB End Labeling (TUDEL), for Specific, Direct in situ Labeling of DNA Double Strand Breaks.- Ligand-directed GPCR Antibody Discovery.- Self-Induced Back-Action Actuated Nanopore Electrophoresis (Sane) (File #Sensor For Label-Free Detection Of Cancer Immunotherapy-Relevant Antibody-Ligand Interactions.- Incorporating, quantifying, and leveraging noncanonical amino acids in yeast.- Nuclease-assisted, multiplexed minor-allele enrichment: application in liquid biopsy of cancer.- Implementation of Ion Mobility Spectrometry-Based Separations in Structures for Lossless Ion Manipulations (SLIM).- Pleural Effusion Aspirate for use in 3D Lung Cancer Modeling and Chemotherapy Screening.- Using Optical Tweezers to Dissect Allosteric Communication Networks in Protein Kinases.- Focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN).- Extracellular pH mapping as therapeutic readout of drug delivery in glioblastoma.- Charge-Based Multi-Arm Avidin Nano-construct as a Platform Technology for Applications in Drug Delivery.- Chemical Modification of Proteins and Their Intracellular Delivery Using Lipidoid Nanoparticles.- Generation of Membrane-derived Nanovesicles by Nitrogen Cavitation for Drug Targeting Delivery and Immunization.- Laboratory-scale production of sterile targeted microbubbles.- Adeno-associated viral vector immobilization and local delivery from bare metal surfaces.- Decellularization and Recellularization Methods for Avian Lungs: An Alternative Approach for Use in Pulmonary Therapeutics.- Methods for Forming Human Lymphatic Microvessels In Vitro and Assessing Their Drainage Function.- Polymer Based Micro-Nanostructured Scaffolds for Bone Tissue Engineering.- Biodegradable electrospun nanofibrous scaffolds for bone tissue engineering.- Bio-Tribometer for the Assessment of Cell and Tissue Toxicity of Orthopedic Metal Implant.- Methods for Quantifying Neutrophil Extracellular Traps on Biomaterials.- In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.- Computational modeling and simulation to quantify the effects of obstructions on the performance of ventricular catheters used in hydrocephalus treatment.- Selection of Cancer Stem Cell--targeting Agents Using Bacteriophage Display.- Nano-Scintillator-Based X-Ray Induced Photodynamic Therapy.- Methods to measure the inhibition of ABCG2 transporter and ferrochelatase activityto enhance aminolevulinic acid-protoporphyrin IX fluorescence-guided tumor detection and resection.- Macroscopic Fluorescence Lifetime Imaging for Monitoring of Drug-Target Engagement.- Tumor in vivo Imaging with a New Peptide-based Fluorescent Probe.- Thermal Ablation Treatment for Cervical Precancer (Cervical Intraepithelial Neoplasia grade 2 or higher [CIN2+]).- Employing Novel Porcine Models of Subcutaneous Pancreatic Cancer to Evaluate Oncological Therapies.