COVID-19 Metabolomics and Diagnosis

Frank N. Crespilho is Professor of Physical-Chemistry at Chemistry Institute of University of Sao Paulo, São Carlos, since 2012. He was Associate Professor of Chemistry at Federal University (UFABC), Brazil (2009-2012), Visiting Associate in Chemistry at California Institute of Technology, Caltech (EUA), and Visiting Professor at Max-Planck-Institute for Solid State Research, Stuttgart, Germany (2016). He was Visiting Professor at Harvard University (2018-2019), and since 2019, he is Fellow of the J. A. P. School of Engineering and Applied Sciences, Harvard University, at the laboratory of Prof. Michael Aziz. He is Coordinator of COVID-19 Network in metabolomics and diagnostics chemistry at the University of São Paulo. He was one of the inventors of the "Popular Fast Test of COVID-19," costing less than a dollar, for mass testing in developing countries. His research interests include fundamental and applied bioelectrochemistry with a distinctive focus on the chemistry of energy, life and health. His work combines physical-chemical methods and instrumentation development timely application to biological fuel cells and bioinspired batteries, biosensors technology, and electron transfer reactions in biological system. His recent work focuses on in situ and operando spectroscopic-electrochemistry elucidation of the electron transfer mechanism involving redox enzyme, proteins, DNA, and drug delivery in single cells. He has made contributions on the field of protein immobilization processes on solid surfaces, single-cell micro-FTIR analysis, bio-electrocatalysis, and coupling analytical tools to resolve electron transfer mechanism in proteins. He developed a technique named Electrochemical Coupled Vibrational Spectromicroscopy (EVSM), which consists in a multiplex infrared spectroscopy imaging system for monitoring spatially resolved redox chemistry in bioelectrodes, bioinorganic molecules, biological films, and single cells.

Chapter 1. Trends in Electroanalytical Assays for Covid 19 diagnosis.- Chapter 2. Microfluidic devices with electrochemical detection towards covid-19 detection.- Chapter 3. Carbon-based materials for electrochemical sensing of SARS-CoV-2.- Chapter 4. Electrochemical Immunosensor for diagnosis of COVID-19.- Chapter 5. Optical Fibers Sensors for Detection of SARS-CoV-2 Infection.- Chapter 6. Lateral flow assays for COVID-19.- Chapter 7. The use of NMR based metabolomics to discriminate patients with viral diseases.- Chapter 8. Application of quality statistical tools for the evaluation of diagnostic tests for SARS-CoV-2 detection.