Molecular Mechanisms of Hypercoagulable States

The hypercoagulable states are a group of inherited and acquired disorders which lead to a propensity for thrombosis. This text assembles a complete picture of current understanding of the molecular basis of hypercoagulable states.

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The hypercoagulable states are a group of inherited and acquired disorders which lead to a propensity for thrombosis. It is now recognized that there are a number of specific genetic abnormalities, including specific mutations in antithrombotic genes, which cause inherited hypercoagulable states, also termed thrombophilias. There has been an explosion of research and information on understanding the molecular basis of regulation of haemostasis and the identification of molecular abnormalities that cause hypercoagulability. This text assembles a complete picture of current understanding of the molecular basis of hypercoagulable states.