Optimization of Pharmaceutical Processes

lt;b> Antonios Fytopoulos is currently a PhD candidate at KU Leuven. He graduated from the Hellenic Army Academy in 2006 as an officer and pursued a military career, where he received numerous awards and currently, he holds the rank of Major. In 2018 he received his diploma from the School of Chemical Engineering of the National Technical University of Athens, where he graduated in the top 5% of his class. His research interests include crystallization, process optimization, modeling and deracemization methods. His current work focuses on Population balance - based optimization of Viedma Deracemization. He has participated and presented his research at several national and international conferences and coauthored articles in international peer-reviewed journals.
Dr. Rohit Ramachandran is currently Associate Professor & Chancellor's Scholar at the Dept. of Chemical & Biochemical Engineering and the Engineering Research Center of Structured Organic Particulates, at Rutgers University. He received his B.Eng and M.Eng in Chemical Engineering, with a minor in Law, from the National University of Singapore in 2003 and 2005 respectively.  This was followed by his PhD in Chemical Engineering from the Center of Process Systems Engineering, Imperial College London in 2008.  Thereafter he pursued a postdoctoral associate position at the Dept of Chemical Engineering, Massachusetts Institute of Technology (MIT).  His current research interests are in modeling, control, optimization and experimental validation of pharmaceutical and chemical processes.   He has published more than 100 peer reviewed journal articles and has presented his work at numerous national and international conferences as well as at invited seminars at various universities and industrial companies. He has won several awards such as the NSF Career award for young faculty, two NIPTE Young investigator awards, the Rutgers Chancellor's Scholar award, the Rutgers Board of Trustees award for research excellence and the AIChE Process to Development QbD award for contributions in pharmaceutical drug product manufacturing.

Process control and intensification of solution crystallization (Gong).- Method of characteristics for the efficient simulation of population balance models (D. Braatz).- Linearized parameter estimation methods for modeled crystallization phenomena using in-line measurements and its application to optimization of partially seeded crystallization in pharmaceutical processes (Hirasawa).- Mathematical modeling of different breakage PBE kernels using Monte Carlo simulation results (Kumar).- Optimization of tablet coatingMayur M Patel Continuous twin screw granulation processing (Douroumis).- Continuous powder feeding: Equipment design and material considerations (Crean).- Ultrasound for improved encapsulation and crystallization with focus on pharmaceutical applications (Gogate).- Nonsmooth modeling for simulation and optimization of continuous pharmaceutical manufacturing processes (Patrascu).- Integrated synthesis, crystallization, filtration and drying of active pharmaceutical ingredients: a model-based digital design framework for process optimization and control (K. Nagy).- Fast model predictive control of modular systems for continuous manufacturing of pharmaceuticals (D. Braatz)..- Dynamic modeling and control of a continuous biopharmaceutical manufacturing plant (Mansouri).- Overview of scheduling methods for pharmaceutical production (T. Maravelias).- Model-based risk assessment of mAb developability (Glassey).- Design framework and tools for solid drug product manufacturing processes (Sugiyama).- Challenges and solutions in drug product process development from a material science perspective (Stauffer).