Epigenetics in Organ Specific Disorders

Dr. Chandra S. Boosani is an Assistant Professor at the Genetics, Epigenetics & Molecular Biology Lab, within the Department of Translational Research, at the College of Osteopathic Medicine, Pacific Western University School of Health Sciences, CA, U.S.A. His research focuses on developing and testing anticancer proteins, and identifying mechanisms of epigenetic drug action, with emphasis on developing recombinant proteins, drug testing in live mice, and analyzing sequencing data. Dr. Boosani has published in such peer reviewed journals as Seminars in Cancer Biology, Blood, Pharmaceuticals, Gene Regulation and Systems Biology, and Protein Expression and Purification. Ritobrata Goswami is a Assistant Professor in the School of Bioscience, IIT Kharagpur, West Bengal, India.

1. Introduction to epigenetic mechanisms
2. Epigenetic signatures that maintain stemness in pluripotent and mesenchymal stem cells
3. Cell-cell and Cell-matrix interactions mediated by histone deacetylases
4. Enhanced cell proliferation and altered gene expression due to actions of DNA methyltransferases
5. Histone deacetylases and regulation of gene expression during cell proliferation
6. Epigenetic mediators that promote cytoskeletal reorganization and cell migration
7. Inhibition of cellular apoptosis and senescence by unique epigenetic proteins
8. Epigenetic mechanisms involved in the regulation of necrosis and pyknosis
9. Epigenetic control over cell division in pathological conditions
10. Regulated expression of tumor suppressor proteins by DNA methyltransferases during cell cycle progression
11. Role of histone deacetylases in regulating cell cycle progression
12. Phenotype switch and cell differentiation in immune and non-immune cells regulated by different epigenetic mediators
13. Epigenetic pathways that promote cellular autophagy
14. Epigenetic inducers of Cell growth and survival
15. Microbial compounds as potential inducers of epigenetic mechanisms during infections
16. Current epigenetic drugs and their target proteins with potential use in disease treatment
17. Prospects of epigenetic drugs in combination therapy