Reactive Oxygen Species

Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine.- Demystifying oxidative stress.- Oxidants in Physiological Processes.- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies.- Part II Targeting antioxidant responses.- Development of Telintra as an Inhibitor of Glutathione S-Transferase P.- Perspectives on the Clinical Development of NRF2-Targeting Drugs.- Part III: Inhibiting ROS formation and toxification.- NOX Inhibitors: From Bench to Naxibs to Bedside.- Nitric Oxide Synthase Inhibitors into the Clinic at Last.- Xanthine Oxidoreductase Inhibitors.- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches.- Inhibition of Myeloperoxidase.- Part IV: Stimulating/substituting ROS.- Effects of Mammalian Thioredoxin Reductase Inhibitors.- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO-) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation.- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers.- Part V: Repairing ROS damage.- Soluble Guanylate Cyclase Stimulators and Activators - Peter Sander.- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.