Genetic Medicine

Barton Childs, M.D., is professor emeritus of pediatrics and biology at the Johns Hopkins University School of Medicine.

Contents:1. IntroductionI. MEDICAL THINKING 2. Inborn Errors and Chemical Individuality 3. The Transition from Oslerian to Garrodian Medicine 4. Individuality and Causes 5. Definitions of DiseaseII. A LOGIC OF DISEASE 6. Biology and Medicine: Contrasts and Convergences 7. A SynthesisIII. SPECIES IDENTITY 8. Lessons from PhylogenyIV. ADAPTIVE FLEXIBILITY: HOMEOSTASIS AND DEVELOPMENT 9. Physiological Homeostasis: The Homeostasis of the Moment 10. Genetic Homeostasis: The Past 11. Developmental Homeostasis: The Lifetime 12. Sociocultural Homeostasis 13. Homeostatic InteractionsV. DESCENT WITH MODIFICATION: GENETIC VARIATION 14. What is a Gene? 15. The Paths of Gene Action 16. Whatever Is, Is Variable 17. The Semantics of Genetics 18. Classification of DiseaseVI. REPRODUCTION, FREQUENCY, AND CONTINUITY 19. The Diploid State 20. Gene Frequency 21. Heterogeneity 22. Unity and Continuity of Disease 23. Heritability 24. InfectionsVII. AN ANALYSIS OF DISEASE IN THREE TIME FRAMES 25. The Moment: Type I Diabetes 26. The Lifetime 27. Biological and Social History, and a Vision of Disease in Three Time FramesVIII. THE LOGIC AND MODERN MEDICINE 28. The Human Genome Project 29. The Medical-Genetic Synthesis and Society 30. A Basis for Medical Education