The Biology of mRNA: Structure and Function

lt;p>Marlene Oeffinger is Associate Research Professor at the Institut de recherches cliniques de Montréal (IRCM) and the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada, and Adjunct Professor in the Division of Experimental Medicine at McGill University. Her laboratory uses Proteomic, RNomic and biochemical approaches to study the regulation, dynamics and functional niches of RNA maturation pathways and their implications in neurodegenerative diseases.

Daniel Zenklusen is an Associate Professor at the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada. His laboratory uses single molecule and super-resolution microscopy approaches to study different aspects of gene expression in single cells, including RNA transport and localization, lncRNAs function and mRNP organization.

Regulation of co-transcriptional mRNP assembly.- mRNA export through the NPC.- Roles of mRNA modifications in gene regulation.- Studying mRNPs using single molecule approaches.- Difference between mRNPs and lncRNAs?.- RNPs and/or sequence motives in mRNA localization.- mRNP structure.- New RNA binding proteins: mRNP composition.- Aggregation of repeats RNAs in neurodegenerative diseases.- mRNA structural organization and translation.- How to decide to make an mRNA  - degradation.- Methods to study mRNP composition.- mRNA-DNA kisses - R-loops.- Forms of mRNA editing and their role in disease.