Vaccination Strategies Against Highly Variable Pathogens

Lars Hangartner, Ph.D. Lars Hangartner is a molecular biologist and immunologist whose research focuses on the humoral response against variable pathogens, such as influenza A virus and HIV. Moreover, he has performed basic studies on measles virus and lymphocytic choriomeningitis virus. He is currently an associate professor at the Scripps Research Institute in La Jolla, California, and his present research investigates Fc/FcGammaR interactions as well as epitope mapping of polyclonal antibody response in the context of HIV vaccine development. Dennis R. Burton, Ph.D. Dennis Burton is the Chair and Professor in the Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, USA and James and Jessie Minor Chair in Immunology. He is the Scientific Director of the IAVI Neutralizing Antibody Center, Director of The Consortium for HIV/AIDS Vaccine Development (CHAVD) at Scripps, and a member of the Ragon Institute of MGH, MIT and Harvard, Boston, USA. His research is focused on infectious disease, in particular the interplay of antibodies and highly mutable viruses, notably HIV. He is interested in the potential of broadly neutralizing antibodies to inform vaccine design.

Successful Vaccines.- Immunogenicity and Immunodominance in Antibody Responses.- Immunogen Design.- Adjuvants.- Tools to screen vaccines.- Targeting glycans on human pathogens for vaccine design.- BnAbs and highly antigenically variable pathogens.