Lessons from Animal Diabetes

Part 1 Pathogenesis in NIDDM: a hypertensive NIDDM model - neonatal stretozotocin diabetes in spontaneously hypertensive rats; sequensive analysis of insulin gene of the NON mouse; vitamin B6 and diabetes; enhancing effects of nicotinic A Ch receptor channel blockers on the neuromuscular blocking action of succinylcholine and its diabetic modification in streptozotocin mice; the pathogenesis of autoimmune diabetes mellitus in the NOD/Shi mouse. Part 2 Insulin secretion and resistance: triphenyltin-chloride-induced diabetes in hamsters; insulin release by glucose anomers in the GK rat; intranuclear filaments in pancreatic beta-cells of NON mice; Vagal regulation of insulin release in VMH-lesioned rats; pioglitazone (AD-4833) improves hepatic insulin resistance in streptozocin-induced diabetic rats. Part 3 Diabetic complications: renal histology and long-term observation of glucose intolerance in NON mice; trace elements in ocular tissues of NOD mouse; peripheral motor neuropathy in spontaneously diabetic WBN/Kob rats; aldose reductase inhibitor prevents complications in WBN rats; bone changes in spontaneously diabetic GK rats. Part 4 New treatment: effect of intestinal disaccharidase inhibitor (AO-128) on NIDDM and IDDM rat models; effect of acarbose dosage on glycemic, cholesterolemic, and triglyceridemic reponses in obese and obese-diabetic corpulent rats.