Sunlight, Vitamin D and Skin Cancer

JÖRG REICHRATH is Professor for Dermatology and Deputy Director of the Clinic for Dermatology, Allergology and Venerology at the Saarland University Hospital in Homburg, Germany. Reichrath has received his academic degrees (Dr. med) from the Saarland University, Germany. His research interests include photobiology, dermato-endocrinology and dermato-oncology. He is a member of numerous national and international scientific organizations, including the German Dermatological Society (DDG), the Deutsche Krebsgesellschaft (DKG), the German Dermatologic Cooperative Oncology Group (DeCOG), and the European Society of Dermatological Research (ESDR). He has been awarded numerous prices including the Arnold-Rikli-price.

Section I: Introduction .- Lessons learned from paleolithic models and evolution for human health: a snap shot on beneficial effects and risks of solar radiation.- Section II: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences (I).- Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need?.- Section III: Solar radiation, Vitamin D and human health.- Vitamin D status and cancer incidence and mortality.- Vitamin D receptors polymorphisms and cancer.- On the relationship between sun exposure and all-cause mortality.- Lindqvist PG (2020) Women with greater sun exposure habits seem to be healthier and to live longer. Are these results in contrast to other research? No.- Section IV: Epidemiology of skin cancer.- Epidemiology of skin cancer and UV radiation - update 2019.- Solar UV exposure and mortality from skin tumors: an update.- Solarium Use and Risk for Malignant Melanoma: many open questions,not the time to close the debate.- Section V: Photocarcinogenesis of skin cancer.- Molecular biology of basal and squamous cell carcinomas.- Human papillomaviruses and skin cancer.- The immune system and pathogenesis of melanoma and nonnmelanoma skin cancer.- Section VI: The relevance of the vitamin D endocrine system for skin cancer.- Protection from ultraviolet damage and photocarcinogenesis by vitamin D compounds.- The role of classical and novel forms of vitamin D in the pathogenesis and  progression of non-melanoma skin cancers.- The Vitamin D Receptor as tumor suppressor in skin.- Cancer prevention in skin and other tissues via cross-talk between vitamin D- and p53- signalling.- Section VII: Prevention and Management of Skin Cancer.- Sunscreens in the United States: Current Status and Future Outlook.- A handful of sunscreen for whole body application.- Sunlight, vitamin D and Xeroderma pigmentosum.- Update: Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs).- Section VIII: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences - II. promise and outlook .- Ultraviolet exposure scenarios: balancing risks of erythema and cutaneous vitamin D synthesis.- The Paleolithic nutrition model in relation to ultraviolet light and vitamin D.- Index.