Central Nervous System Metastases

Rohan Ramakrishna Department of Neurological Surgery NewYork-Presbyterian/Weill Cornell Medicine Director, Brain Metastases Program New York, NY USA Rajiv S. Magge Department of Neurology NewYork-Presbyterian/Weill Cornell Medicine New York, NY USA Ali A. Baaj Department of Neurological Surgery NewYork-Presbyterian/Weill Cornell Medicine New York, NY USA Jonathan P.S. Knisely Department of Radiation Oncology NewYork-Presbyterian/Weill Cornell Medicine New York, NY USA

Epidemiology and Socioeconomic Impact of CNS Metastases.- Basic Biology of Brain Metastasis.- Preclinical Models of Brain Metastasis.- Pathology of Brain Metastases.- Role of Precision Medicine in Patients With CNS Metastasis.- Classification of Brain Metastases.- The Role of Advanced Imaging in the Management of Brain Metastases.- Clinical Presentation of Central Nervous System Metastases.- Management of Seizures in Brain Metastases.- Cerebrovascular Complications in Patients With Cancer.- Mood Disorders in Patients With CNS Metastases.- Leptomeningeal Disease and the Role of Intrathecal Therapy.- Paraneoplastic Neurological Disorders.- Systemic Therapy of Brain Metastases: Lung Cancer.- Systemic Therapy of Brain Metastases: Breast Cancer.- Systemic Therapy for Brain Metastases: Melanoma.- Systemic Therapy for Brain Metastases in Other Primary Cancers (Genitourinary, Gastrointestinal, Gynecology, Head/Neck).- Management of Solid Tumor CNS Metastases in Children.- Basic Radiobiology and Radiation Physics Primer.- Role of Whole Brain Radiotherapy.- Stereotactic Radiosurgery Technology.- Stereotactic Radiosurgery - Indications and Outcomes in Central Nervous System and Skull Base Metastases.- Hypofractionated Stereotactic Radiosurgery (HF-SRS) in the Treatment of Brain Metastases.- Challenges and Controversies in Stereotactic Radiosurgery.- Synergy of Immunotherapy and Radiosurgery.- Salvage Irradiation for Patients With Recurrent Brain Metastases.- Applications of Stereotactic Radiosurgery for Brain Metastases.- Radiation Necrosis Following the Radiosurgical Treatment of Brain Metastases.- Neurocognitive Effects of Brain Metastases and Their Treatment.- The Role of Surgery in the Management of Brain Metastases.- Intraoperative Brachytherapy for Resected Brain Metastases.- Laser Interstitial Thermal Therapy for Brain Metastases and Radiation Necrosis.- Preventing Cranial Wound Complications in Cancer Patients.- Introduction to Spinal Metastases.- Epidemiology of Spinal Metastatic Disease.- Bone Metabolism in Cancer.- Systemic Therapies for Patients With Metastatic Spinal Disease.- The Role of Advanced Imaging in Spinal Metastases.- Decision Making Algorithms for Surgical Treatment of Spine Metastatic Disease.- Biomechanics of Spinal Fixation in Metastatic Disease.- Separation Surgery for Spinal Metastases.- Vertebrectomy for Spinal Metastases.- Minimally Invasive Surgery for Spinal Metastases.- Deformity Secondary to Vertebral Body Metastases.- Postoperative Complications and Spinal Metastases.- Vertebral Augmentation Procedures for Treatment of Pathologic Vertebral Body Fractures.- Spinal Laser Interstitial Thermal Therapy for Metastatic Tumors.- Optimizing Wound Healing in Metastatic Spine Surgery.- Contemporary Radiation for Spinal Metastasis and Spinal Cord Compression.- Intraoperative Radiation for Spinal Metastatic Disease.- Approach to Pain in Patients with Central Nervous System Metastases.- Interventions for Refractory Pain in Cancer Patients.- Complementary and Integrative Therapies (CIM) in Patients With CNS Metastasis.- The Palliative Care of Patients With Brain Metastases.