Immunosuppression and Human Malignancy

Induction of Suppressor Cells by Immunostimulants.- 1. Introduction.- 2. Induction of Suppressor Cells by BCG.- 3. Induction of Suppressor Cells by C. parvum and Other Immunostimulants.- 4. Conclusions.- Control of Natural Killer Cells by Suppressor Cells.- 1. Introduction.- 2. Activity of Anti-NK Suppressor Cells in Normal Animals.- 3. Activation of Anti-NK Suppressor Cells by Irradiation or Treatment with Estrogen.- 4. Activation of Anti-NK Suppressor Cells by External Stimulators.- 5. Activity of Anti-NK Suppressor Cells in TBH.- 6. Mechanisms.- 7. Suppression or Artifact?.- 8. Suppressor Cells Controlling NK-Cell Activity in Human Beings.- Antigenic Entities of the Tumor That Induce Suppressor Cells May Prevent the Potentiation of Coexpressed Immunogenic Entities.- Suppressor Cells in Human Malignant Diseases.- 1. Introduction.- 2. Hodgkin’s Disease.- 3. Non-Hodgkin’s Lymphomas, Leukemias, and Multiple Myelomas.- 4. Cancer of the Head and Neck.- 5. Lung Cancer.- 6. Alimentary-Tract Malignancies.- 7. Genitourinary Malignancies.- 8. Gynecologic Malignancies.- 9. Cancer of the Breast.- 10. Melanoma and Other Skin Malignancies.- 11. Malignancies of the Central Nervous System.- 12. Some Considerations of the Role of Immune Suppression in Human Malignancy.- 13. The Effect of Antineoplastic Chemotherapy on Human Suppressor-Cell Activity.- Suppressor Cells and Malignancy in Animal Experimental Models: A Brief Summary of Recent Findings.- 1. Suppressor Macrophages and “Null” Cells.- 2. “Sneaking Through” of Low Doses of Tumor Cells Is Mediated by Suppressor Cells.- 3. Suppressor T Cells and Their Mechanism of Action.- 4. Suppressor T Cell Lines and Clones.- 5. Suppression of Concomitant Immunity.- 6. Immunotherapy Based on Suppressor Cells Eradication.- 7.Immunoregulation of Antitumor Autoimmunity by Suppressor T Cells.- General Conclusions.- References.