100 Years of Human Chorionic Gonadotropin

Dr. Cole has served on the journal editorial board from 1994-2001 as the Editor of "Trophoblast Disease Update". He has written more than 100 articles on hCG structure, physiology and immunoassay and on clinical applications of hCG or hCG-related molecules. He has a 1.17 FWCI in the Medicine category of SciVal where he has published throughout the various disciplines and maintains an average of 12.6 citations per article from 2009-2014. He has experience with international, single, and institutional collaboration. Awards and recognition for Dr. Cole include the Institute for Anticancer Research, Biannual Prize for best research; American Association for Clinical Chemistry, Most Outstanding Research Contributor to Clinical Chemistry Prize; Gynecology Oncology, Outstanding Speaker Award; and International Society for Study of Trophoblastic Disease, Gold Medal for most outstanding research. Dr. Butler attained his PhD from the University of London and after a Post-Doctoral Fellowship at Yale University School of Medicine he became an Assistant Professor at the University of New Mexico with the USA hCG Reference Service. Steve returned to the UK and, following positions at Queen Mary University of London and London Metropolitan University he spent seven years at Middlesex University as Reader (Associate Professor) in Biomedical Diagnostics. Dr Butler has been a Director for medical diagnostics companies and and is now a consultant biomedical diagnostics expert with a particular interest in diagnostics and therapeutics relating to hCG in pregnancy and cancer. He has published over 80 peer reviewed scientific articles, reviews, letters, patents, abstracts and book chapters in the field of molecular diagnostics. He is a global opinion leader on the structure and function of human chorionic gonadotropin (hCG) and its role as a diagnostic marker in fertility, pregnancy and cancer.

Forward- 100 Years of hCG Introduction - 100 Years of hCG - Meet the Editors and the Authors Section 1 - Genes and Structure Chapter 1.1 - Isolating C5 and B152 - Anecdote Chapter 1.2 - Evolutionary, structural and physiological differences between hCG and LH Chapter 1.3 - hCG and Human Evolution - The Master Molecule Chapter 1.4 - Human Chorionic Gonadotropin: Different Origins, Glycoforms and Functions during Pregnancy Chapter 1.5 - Molecular Modelling of hCG: influence of glycosylation and nicking on molecular folding and epitope recognition Chapter 1.6 - Why is hCG Glycosylated Section 2 - Detection and Quantitation Chapter 2.1 - Detecting hCG that’s not there - Annecdote Chapter 2.2 - Quantification of hCG by MALDI ToF Mass Spectrometry Chapter 2.3 - Pregnancy failures and false positive hCG tests Chapter 2.4 - Home Pregnancy Tests Chapter 2.5 - Human Chorionic Gonadotropin determination using mass spectrometry Chapter 2.6 - Beta core fragment as a standard quality control in MALDI Section 3 - Pregnancy and Fertility Chapter 3.1 - hCG as an LH analogue - Anecdote Chapter 3.2 - The role of hCG in endometrial receptivity and embryo implantation Chapter 3.3 - Qualitative Analysis of hCG Variants and Glycoforms in Urine Chapter 3.4 - Phenotypic characterization of a transgenic mouse model overproducing hCG Chapter 3.5 - The Role of Human Chorionic Gonadotropin in Reproductive Medicine Chapter 3.6 - Pregnancy and hCG Chapter 3.7 - My Journey with Human Chorionic Gonadotropin: development of a Unique Vaccine for control of fertility Chapter 3.8 - Evaluation of Delivery Vectors for Active Immunisation with Synthetic Peptides of hCG as a Fertility Control Method Section 4 - Cancer and Therapy Chapter 4.1 - How hCG and a failed experiment changed my life - Anecdote Chapter 4.2 - Human chorionic gonadotropin in cancer – where are we? Chapter 4.3 - LH/hCG-receptor independent activities of hCG and hCGß Chapter 4.4 - The Role of the Free Beta Subunit of Human Chorionic Gonadotropin in Human Malignancy Chapter 4.5 - hCG and Gestational Trophoblastic Diseases - Hydatidiform Mole and Choriocarcinoma Chapter 4.6 - Immunotherapy of Advanced Stage, Invariably Drug Resistant Cancer Expressing ectopically hCG Chapter 4.7 – A Potential Cure for Cancer Section 5 - Conclusion Chapter 5.1 - Where has hCG research been? What is hCG research doing? Which direction will it go in the future?