Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis

Padma V. Devarajan, PhD (Tech), is Professor in Pharmacy and former Head, Department of Pharmaceutical Sciences and Technology at the Institute of Chemical Technology (ICT), Mumbai, India. Her research interests include nano carriers for targeted delivery in cancer and infectious diseases, innovative approaches in scale-up of nano drug delivery systems (DDS), bioenhancement strategies, and mucosal DDS as alternatives to parenteral administration for protein and nucleic acid delivery. She is editor of Targeted Drug Delivery-Concepts and Design, published by Springer, author of several book chapters and has publications in peer reviewed high impact journals. She is a member on the Editorial board of European Journal of Drug Metabolism and Pharmacokinetics and the Asian Journal of Pharmaceutical Sciences and peer reviewer for a number of International Journals. She has served as Board Member, Member on the Board of Scientific Advisors ,   Chair of the Young Scientist Mentor Protégé Sub-committee of the Controlled Release Society Inc., USA and Chair- Outstanding Paper Award Committee, Drug Development and Translational research. Prof. Devarajan is a nominated Fellow of the Maharashtra Academy of Sciences, India, and recipient of number of awards including the American Association of Indian Pharmaceutical Scientists (AAiPS) Distinguished Educator and Researcher Award, and Innovation Awards for pioneering research in Nanotechnology and Targeted Drug Delivery Systems. Prajakta Dandekar received her PhD from the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai. Her doctoral research involved the development of polymeric nanoparticles for natural therapeutic agents. Later, she joined the Department of Macromolecular Organic Chemistry, University of Saarland, Saarbrucken, as a post-doctoral researcher and was involved in formulating nanoparticles of new hydrophobic starch polymers for encapsulating hydrophobic anti-cancer actives. She was the first woman scientist from India to be awarded the European Respiratory Society-Marie Curie Joint Postdoctoral Fellowship (long-term) and conducted the associated research involving formulation of nanoparticles for intracellular siRNA delivery at the Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrucken, Germany. From January 2012 until October 2014, she worked as Dr. John Kapoor Assistant Professorin Pharmaceutical Technology at the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai. Currently, she is UGC Assistant Professor in Engineering Sciences, in the same department. Her research interests involve design of siRNA-polymer nanocarriers, development of in vitro 2D and 3D cellular models, and developing biopolymer-scaffolds and microfluidic devices for tissue engineering. Anisha A. D’Souza is currently working as Research Formulation Scientist at Piramal Enterprises Limited, Mumbai. She received her PhD (Tech.) in Pharmaceutics from the Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai (ICT, Formerly known as UDCT). She was the recipient of the most coveted and prestigious ‘Prof. M. M. Sharma Doctoral Fellowship’ at ICT. Subsequently, during her post-doctoral tenure at IIT-Bombay, she has worked on delivery of micronutrients encapsulated nanoparticles incorporated in different cosmetics for improving mother and child health. Her research interest encompasses colloidal drug delivery systems viz., polymeric and solid lipid nanoparticles for enhanced bioavailability, controlled delivery and targeting. She has published research papers and reviews in peer reviewed journals and has coauthored number of book chapters.

Part 1-Introduction and overview.- Intracellular Delivery in Cancer and Infectious Diseases.- Intracellular Delivery by Receptor Mediated Endocytosis.- Part 2-Receptor and Receptor Medicated Endocytosis in Cancer.- Receptors Relevant for  Cancer Therapeutics.- (chapters 3-8) .- Part 3-Receptors and Receptor Medicated Endocytosis in Infectious Diseases.- Receptors Relevant for Infectious Disease Therapeutics.- (chapters 9-13).- Part 4-Common Receptors for Receptors and Receptor Mediated Endocytosis in Cancer and Infectious Diseases.- Chapters 14-17).- Receptors Relevant for Cancer and Infectious Disease Therapeutics.- Part 5-Models for Evaluation of Targeted Delivery in Cancer and infectious Diseases.- In vitro and in vivo Models for Cancer and Infectious Diseases.- In vitro and in vivo Models for Infectious Diseases.- Part 6- Regulatory and Toxicity Issues.- Regulatory and Toxicity Issues in TargetedDelivery.