The Neuropharmacology of Alcohol (eBook)

Part 1. Neurotransmitter systems.- 1. GABAA receptor subtype mechanism and the abuse related effects of ethanol: Genetic and pharmacological evidence.- 2. Presynaptic Ethanol Actions: Potential Roles in Ethanol Seeking.- 3. Dynamic adaptation in neurosteroid networks in response to alcohol.- 4. GABA and Glutamate synaptic co-adaptations to chronic ethanol in the striatum.- 5. The cerebellar GABAAR system as a potential target for treating alcohol use disorder.- 6. Do alcohol-related AMPA-type glutamate receptor adaptations promote intake?.- 7. Molecular, neuronal and behavioral effects of ethanol and nicotine interactions.- 8. Cross-species alterations in synaptic dopamine regulation after chronic alcohol exposure.- 9.Central noradrenergic interactions with alcohol and regulation of alcohol related behaviors.- Part 2. Ion Channels.- 10. Voltage-sensitive calcium channels in the brain: Relevance to alcohol intoxication and withdrawal.- 11. Voltage-sensitive potassium channels of the BK type and their coding genes are alcohol targets in neurons.- 12. Chronic alcohol, intrinsic excitability, and potassium channels: Neuroadaptations and drinking behavior.- Part 3. Neuroimmune system.- 13. Hepatic immune system adaptations to alcohol.- 14. Innate immune signaling and alcohol use disorders.- 15.Cytokins in the CNS.- Part 4. Neuropeptides and Genomics.- 16. Corticotropin Releasing Factor (CRF) Neurocircuitry and neuropharmacology in alcohol drinking.- 17. Contribution of dynorphin and orexin neuropeptide systems to the motivational effects of alcohol.- 18. Transcriptional regulators as targets for alcohol pharmacotherapies.- Part 5. Pharmacotherapy.- 19. Advances in Pharmacotherapy Development From Preclinical Animal Studies.- 20. Advances in Pharmacotherapy Development: Human Clinical Studies.