Diagnostic Pathology: Infectious Diseases

Isaac H. Solomon, MD, PhD, is an Associate Pathologist in the Department of Pathology at Brigham and Women's Hospital and an Assistant Professor of Pathology at Harvard Medical School in Boston, Massachusetts. Solomon retains the status of Neurooncology Member at the Dana Farber/Harvard Cancer Center in Boston, Massachusetts. Dan Milner, MD, MSc(Epi), MBA, is a consultant pathologist, executive director, and medical director at Libragem Consulting, LLC, in Palm Springs, California, and an Associate Professor at the Department of Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health in Boston, Massachusetts

Overview

Standard Methods for Infectious Diseases

Molecular Diagnostics

Viral Infections

Morphological Diagnosis of Viral Infections

DNA Viruses

Herpes Simplex Virus 1 and 2 (HSV-1, HSV-2) Infections

Varicella-Zoster Virus (HHV-3) Infections

Epstein-Barr Virus (HHV-4) Infection

Cytomegalovirus (HHV-5) Infections

Kaposi Sarcoma-Associated Herpesvirus (HHV-8) Infection

Adenovirus Infection

Hepatitis B and D Virus Infections

Measles Virus Infection

Parvovirus B19 Infection

JC Virus, BK Virus, and Other Polyomavirus Infections

Pox Virus Infections

Human Papillomavirus Infection

RNA Viruses

Rabies Virus Infection

Respiratory Syncytial Virus Infection

Viral Infections Requiring Ancillary Tests

DNA Viruses

Human Herpesvirus 6 and 7 (HHV-6, HHV-7) Infections

RNA Viruses

Arbovirus Infections

Zika Virus Infection

Ebola, Marburg, and Other Hemorrhagic Fever Virus Infections

Enterovirus Infection

Poliovirus Infection

Lymphocytic Choriomeningitis Virus Infection

Mumps Virus Infection

Rubella

Human Immunodeficiency Virus Infection

Human T-Lymphotropic Virus Type I Infection

Influenza Virus Infections

Parainfluenza Virus Infections

Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Other Coronavirus Infections

Rhinovirus and Other Respiratory Virus Infections

Rotavirus, Norovirus, and Astrovirus Infections

Hepatitis A and E Virus Infections

Hepatitis C Virus Infection

Prion Diseases

Transmissible Spongiform Encephalopathies

Bacterial Infections

Morphological Diagnosis of Bacterial Infections

Bacterial Infections

Anaplasmosis and Ehrlichiosis

Pertussis

Malakoplakia

Actinomycosis

Botryomycosis

Helicobacteriosis

Leprosy

Nocardiosis

Spirochetosis

Whipple Disease

Bacterial Infections Requiring Culture/Ancillary Confirmation

Gram-Positive Bacilli

Bacillus Species Infections

Corynebacterium Species Infections

Listeria Species Infection

Rhodococcus Species Infection

Anaerobes

Gram-Positive Anaerobes

Gram-Negative Anaerobes

Clostridiosis and Other Anaerobic Infections

Gram-Positive Cocci

Staphylococcus Species Infections

Streptococcus and Enterococcus Species Infections

Gram-Negative Bacilli

Gram-Negative Enteric Organisms and Their Infections

Gram-Negative Zoonotic Pathogen Infections

Primary Gram-Negative Respiratory Pathogen Infections

Gram-Negative Cocci

Neisseria and Moraxella Species Infections

Spirochete Bacteria

Borrelia Species Infections

Leptospira Species Infection

Syphilis and Other Treponematoses

Acid-Fast Bacilli

Mycobacterium tuberculosis Complex Infections

Mycobacteria Other Than Tuberculosis Infections

Intracellular Bacterial Infections

Chlamydophila and Chlamydia Species Infections

Rickettsia Species Infection

Coxiella

Fungal Infections

Morphological Diagnosis of Fungal Infections

Fungal Classification and Diagnosis

Aspergillosis

Blastomycosis

Candidiasis

Chromoblastomycosis

Coccidioidomycosis

Cryptococcosis

Histoplasmosis

Mucormycosis

Mycetoma

Paracoccidioidomycosis

Penicilliosis

Phaeohyphomycosis

Pneumocystosis

Rhinosporidiosis

Sporotrichosis

Tineasis

Challenging Morphology in Fungal Infections Requiring Culture/Ancillary Tests

Fusariosis and Other Hyalohyphomycoses

Scedosporiosis

Scopulariopsis Infections

Trichosporonosis

Protozoan Parasitic Infections

Morphologic Diagnosis of Protozoa in Anatomic Pathology

Protozoa Classification and Diagnosis

Gastrointestinal and Other Luminal Protozoa

Balantidiasis

Cryptosporidiosis and Other Coccidia Infections

Entamebiasis

Giardiasis

Microsporidiosis

Trichomoniasis

Intravascular Protozoa

African Trypanosomiasis

Babesiosis

Malaria

Deep Tissue Protozoa

Free-Living Amebiasis

American Trypanosomiasis

Leishmaniasis

Toxoplasmosis

Helminthic Parasitic Infections

Nematodes

Ancylostomiasis and Necatoriasis

Ascariasis

Human Filariasis

Onchocerciasis

Strongyloidiasis

Trichuriasis

Zoonotic Nematode Infections

Trematodes

Schistosomiasis

Other Tissue Trematode Infections

Cestodes

Echinococcosis

Cysticercosis

Coenurosis

Infestations and Other Invertebrate-Related Maladies

Direct Evidence of Invertebrates in Tissue

Myiasis

Scabies

Demodex Infestations

Tungiasis

Indirect Evidence of Invertebrates in Tissue

Tissue Damage From Arachnids and Insects