Histamine Receptors as Drug Targets

Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors.- Development, Characterization, and Validation of Anti-Human H3 Receptor Isoform-Specific Antibodies.- Approaches to Recombinant Histamine H3/H4 Receptor Expression in Mammalian Cells.- Histamine H2 Receptor Biased Signaling Methods.- Ligand-Binding Kinetics on Histamine Receptors.- Methods to Study the Molecular Pharmacology of the Histamine H4 Receptor.- Chemiluminescence: A Sensitive Method for Detecting the Effects of Histamine Receptor Agonists/Antagonists on Neutrophil Oxidative Burst.- Techniques Used in Pharmacological Evaluation of Histamine H4 Receptor Function on Native Human Eosinophils.- Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis.- Methodological Approaches to Study Histamine Pharmacology in the Kidney: From Cell Culture and Cell Imaging to Functional Assays and Electron Microscopy.- Histamine and the Kidney: In Vivo Animal Models.- Methodological Approaches to Investigate the Effects of Histamine Receptor Targeting Compounds in Preclinical Models of Breast Cancer.- Evaluation of Histidine Decarboxylase (HDC) Activity and Human Histamine Receptor 3 (H3R) and HDC mRNA Levels.- Cerebrospinal Fluid Markers in Neuroinflammation: The Paradigm of Optic Neuritis.- In Vivo Diagnostic Procedures for IgE-Mediated Allergic Disorders.- Dermatological Indications of Antihistamines.- Histamine Quantification in Human Blood Samples.