Development of In Vitro Maturation for Human Oocytes

Ri-Cheng Chian, MSc, PhD, Associate Professor, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada Geeta Nargund FRCOG, Medical Director, Create Fertility, Lead consultant in Reproductive Medicine, St George's Hospital NHS Trust, President, International Society for Mild Approaches in Assisted Reproduction (ISMAAR), London, UK

Part I: Ovarian Function.- Ovarian Endocrinology.- Follicular Development and Oocyte Growth.- A New Understanding of the Regulation of Oocyte Meiotic Prophase Arrest and Resumption.- Mitochondria of the Oocyte.- Part II: Natural Cycle IVF and Stimulation Cycle IVF.- Natural Cycle IVF: Summary of the Current Literature.- Follicular Fluid Hormone Profiles in Natural Cycle IVF Patients during Follicular Phase.- Standard Ovarian Stimulation Protocols and Their Outcomes.- Which Women Are Suitable for Natural and Modified Natural Cycle IVF?.- Natural Cycle IVF with Spontaneous LH Surge.- Etiologies and Risk Factors of Ovarian Hyperstimulation Syndrome.- Prevention and Management of Ovarian Hyperstimulation Syndrome.- Part III: Minimal or Mild Stimulation for IVF.- Cumulative Pregnancy Rates after Six Cycles of Modified Natural Cycle IVF.- Minimal Stimulation for IVF with Clomiphene Citrate.- Mild Stimulation Protocols: Combination of Clomiphene Citrate and Recombinant FSH or HMG.- Mild Stimulation Protocol for Poor Ovarian Responders Undergoing IVF.- The Application of Natural Cycle IVF in Primary Ovarian Insufficiency.- Mild Stimulation Protocols for Oncofertility Patients.- Minimally Invasive IVF as an Alternative Treatment Option for Infertile Couples: (INVO) Procedure.- Accessible Infertility Care: From Dream to Reality.- Genetic Aspects of Recurrent Implantation Failure.- Part IV: Development of In Vitro Maturation.- IVM as Clinical Treatment: Overview.- Avoidance of Severe Ovarian Hyperstimulation with IVM Treatment.- Immature Oocyte Retrieval for IVM Treatment.- Laboratory Aspect of IVM Treatment.- Obstetric Outcomes of In Vitro Maturation Treatment and Risk of Congenital Malformations.- Development of IVM Treatment: Combination of Natural Cycle IVF with IVM.