Chemotherapy in Neonates and Infants (eBook)

Carolina Witchmichen Penteado Schmidt is an oncology pharmacist with extensive experience in Pediatric Oncohematology and Chemotherapy in Children.  She is a specialist in Oncological Hospital Pharmacy and also has an MBA in Business Management. She has extensive hospital experience in the field of Pharmacy, Drug Interactions, Pediatrics, Oncology, Hematology, Neonatology, Intensive Health Care and Infectology; and academic experience teaching medical residents of Pediatric Oncohematology program, also pharmacists residents of Child and Adolescent Health program, and teaching in post graduation courses. She is author of the book Drug Therapy and Interactions in Pediatric Oncology, published by Springer.

1. Introduction 1.1. Differences of drug metabolism in neonates 1.2. Differences of drug metabolism in infants 1.3. Chemotherapy in neonates 1.4. Chemotherapy in infants 1.5. Statistics of the diseases in neonates and infants in each continent 1.6. Statistics of Oncohematology treatment of neonates and infants2. Protocols used in chemotherapy treatment of neonates and infants 3. Pharmacokinetics of Chemotherapy Drugs in Neonates and Infants  3.1. Absorption of chemotherapy in Neonates and Infants  3.2. Drug Binding and Distribution by Proteins  3.2.1. Binding Proteins in Neonates  3.2.2. Binding Proteins in Infants  3.2.3. Transport Proteins in Neonates  3.2.4. Transport Proteins in Infants  3.3. Biotransformation by Enzyme Complexes  3.3.1. Enzyme Complexes in Neonates  3.3.2. Enzyme Complexes in Infants  3.3.3. Enzymes which metabolizes chemotherapy - Which can be used when  3.4. Excretion of Hydrosoluble Drugs 3.4.1. Creatinine clearance in Neonates 3.4.2. Creatinine clearance in Infants 3.4.3. pH urinary in Neonates and Infants 3.4.4. Tubular Secretion 3.4.5. Urinary flow in Neonates and Infants 3.5. Excretion of Liposoluble Drugs4. Pharmacodinamics of Chemotherapy Drugs in Neonates and Infants 4.1. Receptors of Chemotherapy Drugs in Neonates 4.2. Receptors of Chemotherapy Drugs in Infants 4.3. Signaling in Neonates 4.4. Signaling in Infants 4.5. Therapeutic Index in Neonates and Infants 4.6. Dose-Response Relation in Neonates  4.7. Dose-Response Relation in Infants5. List of Chemotherapy Drugs in Neonates and Infants 6. List of Adjuvant Drugs in Chemotherapy of Neonates and Infants 7. Drug Interactions in Neonates and Infants 8. Toxicity 9. Tumor Lysis in Neonates and Infants10. Chemotherapy in Neonates and Infants with Congenital Diseases 11. Bone Marrow Transplantation in Neonates and Infants 11.1. Bone Marrow Transplantation in Neonates 11.2. Bone Marrow Transplantation in Infants12. Body Surface of Neonates13. Body Surface of Infants14. Glossary