Nanobiomaterials (eBook)

Dr. Xiumei Wang is professor of biomaterials science at the school of Materials Science and Engineering in Tsinghua University, China. She obtained her Ph.D. in materials science and engineering from Tsinghua University, then did her postdoctoral research at the Center for Musculoskeletal Research of University of Rochester Medical Center, USA, and the Center for Biomedical Engineering of Massachusetts Institute of Technology, USA, from 2005 to 2008. She is a Fellow of Materials Research Society of China and Fellow of Chinese Society for Biomaterials. Dr. Murugan Ramalingam is professor at the Centre for Stem Cell Research, Christian Medical College Campus, India, and adjunct professor at the Tohoku University, Japan. He received his Ph.D. in Biomaterials from the University of Madras, India. After several years at the National Institute of Standards and Technology (NIST) and the National Institute of Health (NIH), USA, he joined the WPI Advanced Institute for Materials Research, Japan, and later on the University of Strasbourg, France. He is also a Fellow of the Institute of Nanotechnology, UK, and Fellow of Royal Society of Chemistry, UK. Dr. Xiangdong Kong is professor at the college of Life Sciences, Zhejiang Sci-Tech University, China. He got the PhD degree in materials and Engineering from Tsinghua University, China. He founded the Institute of Biomaterials and Marine Biological Resources in 2012 and ZSTU-Dentium Joint Research Center, China and Korea, for Biofunctional Materials and Regenerative Medicine in 2014. Dr. Lingyun Zhao is associate professor of cancer nanotechnology at the school of Materials Science and Engineering (MSE) of Tsinghua University, China. She obtained her PhD degree in Chemical and Biomelecular Engineering from the National University of Singapore (NUS) in 2003 under the supervision of Prof. Feng Si-shen, a pioneer and world leader in nanomedicine. She completed her postdoctoral training in the Chemotherapeutic Lab in NUS and then joined Tsinghua University in 2008.

Part I Introduction 1
1 Nanobiomaterials: State of the Art 3
JingWang, Huihua Li, Lingling Tian, and Seeram Ramakrishna
1.1 Introduction 3
1.1.1 Properties of Nanobiomaterials 4
1.1.2 Interaction between Nanobiomaterials and Biological System 4
1.1.3 Biocompatibility and Toxicity of Nanobiomaterials 5
1.2 Nanobiomaterials for Tissue Engineering Applications 6
1.2.1 Vascular Tissue Engineering 7
1.2.2 Neural Tissue Engineering 9
1.2.3 Cartilage Tissue Engineering 12
1.2.4 Bone Tissue Engineering 13
1.3 Nanobiomaterials for Drug Delivery Applications 15
1.3.1 Carbon-Based Nanobiomaterials 15
1.3.2 Silica Nanoparticles 17
1.3.3 Polymer-Based Nanomaterials 18
1.4 Nanobiomaterials for Imaging and Biosensing Applications 18
1.4.1 Polymer-Based Nanobiomaterials 19
1.4.2 Quantum-Dot-Based Nanobiomaterials 19
1.4.3 Magnetic Nanoparticles 21
1.4.4 Gold Nanobiomaterials 22
1.4.5 Organic-Inorganic-Based Materials 23
1.4.6 CNT-Based Nanobiomaterials 23
1.5 Conclusions and Perspectives 24
References 25
Part II Classification of Nanobiomaterials 37
2 Metallic Nanobiomaterials 39
Magesh S, Vasanth G, Revathi A, Geetha Manivasagam, and Murugan Ramalingam
2.1 Introduction 39
2.2 Conventional to Ultrafine-Grained Materials ? A Novel Transformation 40
2.2.1 Bottom-Up Approach 42
2.2.2 Top-Down Approach 43
2.3 Severe Plastic Deformation (SPD) 43
2.3.1 Equal Channel Angular Pressing (ECAP) 43
2.3.2 High-Pressure Torsion (HPT) 45
2.3.3 Accumulative Roll Bonding (ARB) 46
2.3.4 Other SPD Processes 47
2.3.4.1 Multipass Caliber Rolling (MPCR) 47
2.3.4.2 DisintegratedMelt Deposition (DMD) 47
2.4 Mechanical Behavior of Metallic Nanobiomaterials 48
2.5 Corrosion 49
2.5.1 Corrosion Mechanism 50
2.5.2 Passivation of Metallic Biomaterials 50
2.5.3 Biological Environment and Its Influence on Corrosion of Metallic Biomaterials 51
2.5.4 Corrosion Behavior of Metallic Nanobiomaterials 53
2.6 Wear 54
2.6.1 Wear Assessment 55
2.6.2 Wear Aspects of Metallic Nanobiomaterials 56
2.6.2.1 Improved Wear Resistance of Metallic Nanobiomaterials 56
2.6.2.2 Detrimental Wear Properties of Metallic Nanobiomaterials 57
2.6.2.3 No Effect 57
2.7 Biocompatibility of Metallic Nanobiomaterials 57
2.8 Biomedical Application of Metallic Nanobiomaterials 59
2.9 Future Aspects 59
References 60
3 Polymeric Nanobiomaterials 65
Deepti Rana, Keerthana Ramasamy, Samad Ahadian, Geetha Manivasagam, XiumeiWang, and Murugan Ramalingam
3.1 Introduction 65
3.2 Types of Polymeric Nanobiomaterials 66
3.3 Polymeric Nanofibers 67
3.4 Polymeric Nanofibers to Provide Microenvironmental Cues 69
3.5 Biological Relevance of Polymeric Nanofibers 71
3.6 Recent Trends in Polymeric Nanofibers 72
3.6.1 Hybrid Nanofibers 72
3.6.2 Gradient Nanofibers 74
3.7 Applications of Nanofibers in RegenerativeMedicine 75
3.7.1 Bone Tissue Engineering 75
3.7.2 Nerve Tissue Engineering 77
3.7.3 Vascular Tissue Engineering 78
3.8 Concluding Remarks 79
Acknowledgment 80
References 80
4 Carbon-Based Nanobiomaterials 85
Samad Ahadian, Farhad Batmanghelich, Raquel Obregón, Deepti Rana, Javier Ramón-Azcón, Ramin Banan Sadeghian, and Murugan Ramalingam
4.1 Introduction 85
4.2 Tissue Engineering 87
4.2.1 Neural Tissue Engineering 87
4.2.1.1 CNTs in Neural Tissue Engineering 88
4.2.1.2 Graphene in Neural Tissue Engineering 89
4.2.2 Bone Tissue Engineering 89
4.2.2.1 CNTs in Bone Tissue Engineering 89
4.2.2.2 Graphene in Bone Tissue Engineering 92
4.3 Gene and Drug Delivery 92
4.3.1 CNTs in Delivery Systems 92
4.3.2 Graphene in Delivery Systems 93
4.4 Biosensing 93
4.4.1 CNTs in Biosensing 93
4.4.2 Graphene in Biosensing 94
4.5 Biomedical Imaging 95
4.5.1 CNTs in Biomedical Imaging 95
4.5.2 Graphene in Biomedical Imaging 95
4.6 Conclusions 97
References 97
Part III Nanotechnology-Based Approaches in Biomaterials Fabrications 105
5 Molecular Self-Assembly for Nanobiomaterial Fabrication 107
Ling Zhu, Yanlian Yang, and ChenWang
5.1 Introduction 107
5.1.1 Molecular Self-Assembly 107
5.1.2 Nanoscale Interactions andTheir Roles in Self-Asse