Diagnostic Pathology: Gynecological

Marisa R. Nucci, MD is a Professor of Pathology at Harvard Medical School and Vice Chair and Director of Women's and Perinatal Pathology at Brigham and Women's Hospital in Boston, Massachusetts Esther Oliva, MD is a Pathologist at Massachusetts General Hospital and Professor of Pathology at Harvard Medical School in Boston, Massachusetts. Dr. Oliva is also a Gynecologic Cancers Member at the Dana-Farber/Harvard Cancer Center in Boston.

Vulva

Inflammatory Disorders

Lichen Planus

Fixed Drug Eruption

Erythema Multiforme

Plasmacytosis Mucosae (Zoon)

Lichen Sclerosus

Allergic Contact Dermatitis

Psoriasis

Lichen Simplex Chronicus

Foreign Body Granulomas

Verruciform Xanthoma

Cutaneous Crohn Disease

Epidermolytic Hyperkeratosis

Papular Acantholytic Dermatosis

Behçet Disease

Pemphigus

Bullous Pemphigoid

Cicatricial Pemphigoid

Herpes Gestationis

Linear IgA Disease

Herpes Simplex Virus

Syphilis

Chancroid

Molluscum Contagiosum

Dermatophytosis

Candidiasis

Scabetic Infestations

Hidradenitis Suppurativa

Nonneoplastic Lesions

Bartholin Cyst

Endometriosis, Vulva

Fibroepithelial Stromal Polyp

Massive Vulval Edema

Cutaneous Neoplasia

HPV-Related Lesions (Excluding Vulvar Intraepithelial Neoplasia)

Vulvar Intraepithelial Neoplasia

Squamous Cell Carcinoma, Vulva

Basal Cell Carcinoma

Mucosal Melanotic Macule

Common Melanocytic Nevus

Atypical Nevus of Genital Tract

Malignant Melanoma, Vulva

Extramammary Paget Disease

Hidradenoma Papilliferum

Bartholin Gland Carcinoma

Fibroadenoma and Phyllodes Tumor

Syringoma

Mixed Tumor, Vulva

Microcystic Adnexal Carcinoma

Eccrine Spiradenoma

Trichofolliculoma

Trichoepithelioma

Sebaceous Hyperplasia

Sebaceous Carcinoma

Soft Tissue Neoplasia

Angiomyofibroblastoma

Cellular Angiofibroma

Prepubertal Vulval Fibroma

Superficial Angiomyxoma

Deep Aggressive Angiomyxoma

Smooth Muscle Tumors, Vulva

Solitary Fibrous Tumor, Vulva

Dermatofibrosarcoma Protuberans

Epithelioid Sarcoma

Miscellaneous

Granular Cell Tumor

Vagina

Inflammatory Conditions

Desquamative Inflammatory Vaginitis

Ligneous Vaginitis

Malakoplakia

Nonneoplastic Lesions

Vaginal Cysts

Adenosis

Polyps

Fallopian Tube Prolapse

Neoplasms

Mixed Tumor, Vagina

Rhabdomyoma

Vaginal Intraepithelial Neoplasia

Squamous Cell Carcinoma, Vagina

Adenocarcinomas, Nonclear Cell Type

Clear Cell Carcinoma, Vagina

Yolk Sac Tumor, Vagina

Malignant Melanoma, Vagina

Secondary Neoplasms, Vagina

Uterus: Cervix

Nonneoplastic Lesions

Atrophy

Immature Squamous Metaplasia, Cervix

Arias-Stella Reaction

Deciduosis

Tunnel Clusters

Deep Glands and Cysts

Transitional Cell Metaplasia

Tubal and Tuboendometrioid Metaplasia

Microglandular Hyperplasia

Endocervical Glandular Hyperplasia (Diffuse and Lobular)

Endometriosis, Cervix

Endocervicosis

Endocervical Polyp

Ectopic Prostate

Mesonephric Remnants/Hyperplasia

Cervical Infections

Neoplasms

Müllerian Papilloma

Squamous Intraepithelial Lesion/Dysplasia

Squamous Cell Carcinoma, Cervix

Adenocarcinoma In Situ, Including Variants, Cervix

Adenocarcinoma, Usual Type

Adenocarcinoma, Minimal Deviation

Adenocarcinoma, Villoglandular

Adenocarcinoma, Gastric and Intestinal Types, Including Signet Ring Cell Carcinoma

Adenocarcinoma, Endometrioid, Cervix

Adenocarcinoma, Clear Cell, Cervix

Adenocarcinoma, Serous, Cervix

Mesonephric Adenocarcinoma

Adenosquamous Carcinoma, Including Glassy Cell Carcinoma

Adenoid Basal Carcinoma

Adenoid Cystic Carcinoma

Neuroendocrine Tumors

Rhabdomyosarcoma, Cervix

Endocervical-Type Adenomyoma

Müllerian Adenosarcoma, Cervix

Malignant Mixed Müllerian Tumor, Cervix

Lymphomas and Leukemias of Lower Genital Tract

Metastatic/Secondary Tumors to Cervix

Uterus: Corpus

Nonneoplastic Lesions

Endometritis

Endometrial Metaplasias

Endometrial Polyp

Neoplasms

Endometrial Intraepithelial Neoplasia/Atypical Endometrial Hyperplasia

Endometrioid Adenocarcinoma and Variants, Corpus

Mucinous Adenocarcinoma, Corpus

Serous Adenocarcinoma, Corpus

Clear Cell Adenocarcinoma, Corpus

Squamous Cell Carcinoma, Corpus

Neuroendocrine Carcinomas, Corpus

Undifferentiated Carcinoma, Corpus

Benign and Low-Grade Endometrial Stromal Tumors

High-Grade Endometrial Stromal Sarcoma

Uterine Tumors Resembling Ovarian Sex Cord Tumors

Undifferentiated Uterine Sarcoma

Leiomyoma and Variants

Intravenous Leiomyomatosis

Leiomyosarcoma

Perivascular Epithelioid Cell (PEC) Proliferations

Rhabdomyosarcoma, Corpus

Primitive Neuroectodermal Tumor, Peripheral and Central Types

Wilms Tumor

Endometrioid-Type Adenomyoma

Atypical Polypoid Adenomyoma

Müllerian Adenosarcoma, Corpus

Malignant Mixed Müllerian Tumor, Corpus

Adenomatoid Tumor, Corpus

Inflammatory Myofibroblastic Tumor

Alveolar Soft Part Sarcoma

Germ Cell Tumors, Uterus

Lymphoma and Leukemia, Uterus

Secondary Neoplasms, Uterus

Ovary

Nonneoplastic Lesions

Follicular Cysts

Stromal Hyperplasia and Hyperthecosis

Pregnancy Luteoma

Hyperreactio Luteinalis

Large Solitary Luteinized Follicle Cyst of Pregnancy

Torsion

Endometriosis and Deciduosis

Massive Edema and Fibromatosis

Autoimmune Oophoritis

Luteinized Thecoma With Sclerosing Peritonitis

Neoplasms

Epithelial Tumors

Benign Serous Tumors, Ovary

Serous Borderline Tumor, Ovary

High-Grade Serous Adenocarcinoma, Ovary

Low-Grade Serous Adenocarcinoma, Ovary

Endometrioid Adenofibroma/Cystadenofibroma

Endometrioid Borderline Tumor

Endometrioid Adenocarcinoma, Ovary

Mucinous Cystadenoma/Adenofibroma/Cystadenofibroma

Mucinous Borderline Tumor, Intestinal Type

Mucinous Borderline Tumor, Endocervical Type

Mucinous Adenocarcinoma, Ovary

Mucinous Cystic Tumor With Mural Nodules

Borderline Clear Cell Adenofibroma

Clear Cell Carcinoma, Ovary

Benign Brenner Tumor

Proliferating/Borderline Brenner Tumor

Malignant Brenner Tumor

Transitional Cell Carcinoma (Non-Brenner Type)

Small Cell Carcinoma of Ovary, Hypercalcemic Type

Other Primary Epithelial Tumors

Small Cell Carcinoma, Pulmonary Type

Hepatoid Carcinoma

Mixed Epithelial Stromal Tumors

Mesodermal Adenosarcoma

Malignant Mixed Mesodermal Tumor

Stromal Tumors

Adult Granulosa Cell Tumor

Juvenile Granulosa Cell Tumor

Thecoma

Fibromatous Neoplasms

Sclerosing Stromal Tumor

Signet Ring Stromal Tumor

Microcystic Stromal Tumor

Sertoli Cell Tumor

Sertoli-Leydig Cell Tumor

Sex Cord Tumor With Annular Tubules

Sex Cord-Stromal Tumor, Not Otherwise Specified

Steroid Cell Tumor, Not Otherwise Specified

Stromal Luteoma

Leydig Cell Tumor

Mesenchymal Tumors

Smooth Muscle Tumors, Ovary

Ovarian Endometrioid Stromal Sarcoma, Low Grade

Germ Cell Tumors

Dysgerminoma

Yolk Sac Tumor, Ovary

Polyembryoma

Nongestational Choriocarcinoma

Mature Cystic Teratoma

Struma Ovarii

Strumal Carcinoid

Carcinoid Tumor (Insular, Trabecular, and Mucinous)

Immature Teratoma

Secondary Tumors in Teratomas

Primitive Neuroectodermal Tumor, Ovary

Mixed Germ Cell Stromal Tumors

Gonadoblastoma

Unclassified Mixed Germ Cell/Sex Cord-Stromal Tumor

Miscellaneous Primary Tumors

Malignant Mesothelioma, Ovary

Melanoma

Large Cell Neuroendocrine Carcinoma

Metastatic Tumors

Metastatic Colorectal Carcinoma

Metastatic Gastric Carcinoma

Metastatic Appendiceal Tumors

Metastatic Pancreaticobiliary Adenocarcinoma

Metastatic Lung Carcinoma

Metastatic Cervical Carcinoma

Metastatic Uterine Corpus Carcinoma to Ovary

Metastatic Breast Carcinoma

Metastatic Melanoma

Ovarian Lymphomas and Leukemias

Ovarian Involvement by Gastrointestinal Stromal Tumor

Fallopian Tube and Broad Ligament

Nonneoplastic Lesions

Fallopian Tube Metaplasia

Pseudocarcinomatous Hyperplasia

Salpingitis

Endometriosis, Fallopian Tube

Neoplasms

Metaplastic Papillary Tumor

Adenomatoid Tumor, Fallopian Tube

Female Adnexal Tumor of Probable Wolffian Origin

Serous Borderline Tumor, Fallopian Tube

Serous Carcinoma (Including STIC)

Endometrioid Adenocarcinoma, Fallopian Tube

Transitional Cell Carcinoma, Fallopian Tube

Peritoneum

Nonneoplastic Lesions

Benign Müllerian Lesions

Florid Mesothelial Hyperplasia

Peritoneal Inclusion Cysts

Neoplasms

Disseminated Peritoneal Leiomyomatosis

Well-Differentiated Papillary Mesothelioma

Malignant Mesothelioma, Peritoneum

Solitary Fibrous Tumor, Peritoneum

Extragastrointestinal Stromal Tumor

Intraabdominal Desmoplastic Small Round Cell Tumor

Serous Borderline Tumor, Peritoneum

Serous Carcinoma, Peritoneum

Pseudomyxoma Peritonei