The Endothelins

A documented account of the history, chemistry and physiological and pathological importance of the endothelin family of polypeptides, drawing together current data and providing an insight into new areas of research.

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The aim of this text is to provide a factual account of the history, chemistry, and physiological and pathological importance of the endothelin family of polypeptides. These polypeptides are a very recent discovery and their true significance is still being established. However, they are of enormous potential significance, particularly with respect to the functioning of the circulatory system under normal and abnormal conditions. The reader's attention therefore is directed towards the possible involvement of these polypeptides in the aetiology of ischaemic heart disease, cerebrovascular accidents, hypertension, atherosclerosis and renal failure.